The Scientific Oktoberfest will be this years meeting point for some of the internationally most distinguished researchers in the field of Chemistry & Chemical Biology. The CIPSM Scientific Oktoberfest will be held from the 19th to the 20th of September in the Department of Chemistry of the Ludwig-Maximilians-Universität (LMU) München. At the two-day ...

In this study, it is shown that the cytotoxic response of cells as well as the uptake kinetics of nanoparticles (NPs) is cell type dependent. We use silica NPs with a diameter of 310 nm labeled with perylene dye and 304 nm unlabeled particles to evaluate cell type-dependent uptake and cytotoxicity on human vascular endothelial cells (HUVEC) and cancer cells ...

Protein synthesis in all cells is carried out by macromolecular machines called ribosomes. Although the structures of prokaryotic, yeast and protist ribosomes have been determined, the more complex molecular architecture of metazoan 80S ribosomes has so far remained elusive. Here we present structures of Drosophila melanogaster and Homo sapiens 80S ribosomes ...

Trifunctional biotin reagents incorporating cleavable linkers are evaluated for their usage in protein enrichment. A linker based on the Dde protecting group leads to efficient release of protein targets under mild conditions. It additionally contains a masked trypsin cleavage site, which eliminates the majority of the tag during tryptic digestion.

Cohesin plays an important role in chromatid cohesion and has additional functions in higher-order chromatin organization and in transcriptional regulation. The binding of cohesin to euchromatic regions is largely mediated by CTCF or the mediator complex. However, it is currently unknown how cohesin is recruited to pericentric heterochromatin in mammalian ...

The last step in the biosynthetic pathway of the key strawberry flavor compound 4-hydroxy-2,5-dimethyl-3(2H)-furanone (HDMF) is catalyzed by Fragaria x ananassa enone oxidoreductase (FaEO), earlier putatively assigned as quinone oxidoreductase (FaQR). The ripening-induced enzyme catalyzes the reduction of the exocyclic double bond of the highly reactive ...

Significant advances during the last decade in the field of small-molecule modulators of protein–protein interactions have raised general awareness of the fact that the modulation of protein–protein interactions has tremendous potential for both basic and applied science.[1] Some of the most advanced orthosteric inhibitors of protein–protein ...

Many processes in the regulation of gene expression and signaling involve the formation of protein complexes involving multi-domain proteins. Individual domains that mediate protein-protein and protein-nucleic acid interactions are typically connected by flexible linkers, which contribute to conformational dynamics and enable the formation of complexes with ...

Histone lysine (K) methylation has been shown to play a fundamental role in modulating chromatin architecture and regulation of gene expression. Here we report on the identification of histone H3K56, located at the pivotal, nucleosome DNA entry/exit point, as a novel methylation site that is evolutionary conserved. We identify trimethylation of H3K56 ...

Tet proteins oxidize 5-methylcytosine (mC) to generate 5-hydroxymethyl (hmC), 5-formyl (fC), and 5-carboxylcytosine (caC). The exact function of these oxidative cytosine bases remains elusive. We applied quantitative mass-spectrometry-based proteomics to identify readers for mC and hmC in mouse embryonic stem cells (mESC), neuronal progenitor cells (NPC), ...

Resistance to drugs targeting human thymidylate synthase (TS) poses a major challenge in the field of anti-cancer therapeutics. Overexpression of the TS protein has been implicated as one of the factors leading to the development of resistance. Therefore, repressing translation by targeting the TS mRNA could help to overcome this problem. In this study, we ...

We report an efficient synthesis of the hypermodified natural tRNA modifications wybutosine (yW) and hydroxywybutosine (OHyW). We also describe the preparation of isotopically labeled analogues for precise quantification of yW and OHyW in different tissues including plant materials. The synthesis involved the formation of the unusual tricyclic ring structure ...

Antimicrobial peptides are important defense compounds of higher organisms that can be used as therapeutic agents against bacterial and/or viral infections. We designed several antimicrobial peptides containing hydrophobic and positively charged clusters that are active against plant and human pathogens. Especially peptide SP1-1 is highly active with a MIC ...

Covalent chemical probes enable investigation of a desired fraction of the proteome. It is possible to adjust the selectivity of these probes, so they either react with a certain amino acid in all proteins, a class of proteins or only a single protein species. A combination of specific reactive groups with additional recognition elements can fine tune probes ...

This study examines the absolute quantification of particle uptake into cells. Methods: We developed a novel method to analyze stacks of confocal fluorescence images of single cells interacting with nano- and micro-particles. Particle_in_Cell-3D is a freely available ImageJ macro. During the image analysis routine, single cells are reconstructed in 3D and ...

Rhomboid proteases are evolutionary conserved intramembrane serine proteases. Because of their emerging role in many important biological pathways, rhomboids are potential drug targets. Unfortunately, few chemical tools are available for their study. Here, we describe a mass spectrometry-based assay to measure rhomboid substrate cleavage and inhibition. We ...

DEAF-1 is an important transcriptional regulator that is required for embryonic development and is linked to clinical depression and suicidal behavior in humans. It comprises various structural domains, including a SAND domain that mediates DNA binding and a MYND domain, a cysteine-rich module organized in a Cys4-Cys2-His-Cys (C4-C2HC) tandem zinc binding ...

Maintenance of genomic integrity is essential to ensure normal organismal development and to prevent diseases such as cancer. Nuclear DNA is packaged into chromatin, and thus genome maintenance can be influenced by distinct chromatin environments. In particular, post-translational modifications of histones have emerged as key regulators of genomic integrity. ...

The circadian clock is constituted by a complex molecular network that integrates a number of regulatory cues needed to maintain organismal homeostasis. To this effect, posttranslational modifications of clock proteins modulate circadian rhythms and are thought to convert physiological signals into changes in protein regulatory function. To explore ...

The tumor suppressor protein p53 is often referred to as the guardian of the genome. In the past, controversial findings have been presented for the role of the C-terminal regulatory domain (RD) of p53 as both a negative regulator and a positive regulator of p53 activity. However, the underlying mechanism remained enigmatic. To understand the function of the ...

The Scientific Oktoberfest will be this years meeting point for some of the internationally most distinguished researchers in the field of Chemistry & Chemical Biology. The CIPSM Scientific Oktoberfest will be held from the 19th to the 20th of September in the Department of Chemistry of the Ludwig-Maximilians-Universität (LMU) München. At the two-day ...

The LMU-Harvard Young Scientists’ Forum (YSF), represented by MCN and CIPSM, seeks to unite Ph.D. students and postdoctoral fellows from the Harvard University and the Ludwig-Maximilians-Universität (LMU) with core faculty from the two universities to create a framework for an interdisciplinary exchange of ideas. This year’s conference will be held from the ...

Excursion of students from the CIPSM graduate educational program to the Bayer AG as part of the lecture series on Innovations Management of Bayer AGs Board of Management Member Wolfgang Plischke.

During the CIPSM- Bayer HealthCare-Workshop 2012 researchers from Bayer HealthCare Pharmaceuticals and CIPSM will find time to vividly discuss the latest research trends in the field of protein science .

im Rahmen des CIPSM Graduate Programmes hält Prof. Dr. Wolfgang Plischke (Vorstandsmitglied der Bayer Holding AG) die Vorlesung: "Innovationsmanagement und globale Herausforderungen" am Montag,den 12. November 2012, von 13:00 bis 15:00 im Baeyer-HS der Fakultät für Chemie und Pharmazie der LMU in Großhadern. Wir freuen uns Ihre DoktorandenInnen dazu einladen ...

Prof. Dr. Lois Weisman will talk about: "From yeast to humans: Insights into myosin V based transport and phosphoinositide signalling".

Prof Dr. Angela Kramer will talk about Splicing factor SF1: Protein partners and RNA targets

Round Table : "Tips for sucess as a scientist: A focus on scientific publishing" mit Frau Prof. Jane Langdale, Oxford University, Achtung: Die Teilnehmerzahl dieses Seminars ist begrenzt (noch 13 freie Plätze), Bitte melden Sie sich verbindlich bis zum 15.06.12 per E-Mail an.

Frau Prof. Schmitz-Streit will talk about: "Non-coding RNAs, newly identified players in regulating the N-metabolism of Methanosarcina mazei"

The LMU-Harvard Young Scientists’ Forum (YSF), represented by MCN and CIPSM, seeks to unite Ph.D. students and postdoctoral fellows from the Harvard University and the Ludwig-Maximilians-Universität (LMU) with core faculty from the two universities to create a framework for an interdisciplinary exchange of ideas. This year’s conference will be held at ...

Thank you! CIPSM has once more been selected as a Cluster of Excellence in the German Excellence Initiative. In the next 5 years CIPSM will try to make sure, that it is here to stay. We thank all the people that helped to make that possible.

Prof. Dr. Luisa Figueiredo will talk about: "Chromatin dynamics and antigenic variation in African trypanosomes"

Prof. Dr. Karina Xavier will talk about: "Interference with bacterial inter-species quorum sensing"

CIPSM-Excursion to the Bayer AG as part of the lecture on Innovations Management of Bayer AGs Board of Management Member Wolfgang Plischke.

Die erste wichtige Etappe, die Wissenschaftlerinnen auf dem Weg zur Professur meistern müssen, ist die Qualifikations-phase, etwa als wissenschaftliche Mitarbeiterin, Junior-professorin oder Professurvertreterin. Ein unverzichtbarer Baustein neben der wissenschaftlichen Arbeit ist dabei das „Networking“ - ein Prozess, dem Wissenschaftlerinnen besondere ...

im Rahmen des CIPSM Graduate Programmes hält Prof. Dr. Wolfgang Plischke (Vorstandsmitglied der Bayer Holding AG) die Vorlesung: "Innovationsmanagement und globale Herausforderungen" am Montag,den 12. Dezember 2011, von 13:00 bis 15:00 im Bayer Hörsaal der Fakultät für Chemie und Pharmazie der LMU in Großhadern. Wir freuen uns Ihre DoktorandenInnen dazu ...

im Rahmen des CIPSM Graduate Programmes hält Prof. Dr. Wolfgang Plischke (Vorstandsmitglied der Bayer Holding AG) die Vorlesung: "Innovationsmanagement und globale Herausforderungen" am Montag,den 12. Dezember 2011, von 13:00 bis 15:00 im Bayer Hörsaal der Fakultät für Chemie und Pharmazie der LMU in Großhadern. Wir freuen uns Ihre DoktorandenInnen dazu ...

Dr. Elisa Izaurralde will talk about: "Mechanisms of miRNA-mediated gene silencing".

Thanks to everyone of the 360 people who attended the „Scientific Oktoberfest 2011“! We were able to experience amazing science combined with a awesome spirit. Thank you! Here you can see some impressions.

The „Scientific Oktoberfest“ will be this years meeting point for some of the internationally most distinguished researchers in the field of Chemical Biology. The so-called „CIPSM Fest of Chemical Biology“ will be held from the 15th to the 16th of September in the Department of Chemistry of the Ludwig-Maximilians-Universität (LMU) München. At the two-day ...

The LMU-Harvard Young Scientists’ Forum (YSF), represented by MCN and CIPSM, seeks to unite Ph.D. students and postdoctoral fellows from the Harvard University and the Ludwig-Maximilians-Universität (LMU) with core faculty from the two universities to create a framework for an interdisciplinary exchange of ideas. This year’s conference will be held from the ...

Karla Neugebauer will talk about: "The complex(ed) life of mRNA: from transcription and splicing on chromatin to mRNPs"

Gerlind Wallont will talk about: "A persistant problem - traditional gender roles hold back female scientists"

CIPSM sponsors the "Alpenforum 2011" which will hit Oberammergau from 20th to 22th Mai 2011! The event is dedicated to straighten contacts between young chemists and companies. Be there or be square!

CIPSM-Excursion to the Bayer AG as part of the lecture on Innovations Management of Bayer AGs Board of Management Member Wolfgang Plischke.

CIPSM Lecture Prof. Dr. Michael Rosen

Wendy Gilbert will talk about: "Adapting to altered 'translatomes' through functional specialization of ribosomes".

Symposium “Frontiers in Medicinal Chemistry“

Susanne Häussler will talk about:"Pseudomonas aeruginosa: Mechanism of persistence"

Inken Lind will talk about "Wissenschaft und (verhinderte) Elternschaft - Ein Thema für Männer und Frauen?"

Die Vorlesung umfasst 2 Blöcke a zwei Doppelstunden inkl. Diskussion im WS 2010/11 und richtet sich an Studentinnen/en im Hauptsstudium und Doktorandinnen/en aller Fachrichtungen. Daten: 5. November 2010 und 14. Januar 2011 jeweils von 13:00-17:00 im Baeyer-Hörsaal, Department Chemie & Biochemie der LMU, Butenandtstr. 13, 81377 Großhadern. Nach ...

Die Vorlesung umfasst 2 Blöcke a zwei Doppelstunden inkl. Diskussion im WS 2010/11 und richtet sich an Studentinnen/en im Hauptsstudium und Doktorandinnen/en aller Fachrichtungen. Daten: 5. November 2010 und 14. Januar 2011 jeweils von 13:00-17:00 im Baeyer-Hörsaal, Department Chemie & Biochemie der LMU, Butenandtstr. 13, 81377 Großhadern. Nach ...

During the CIPSM-BSP-Workshop 2010 researchers from Bayer Schering Pharma and CIPSM will find time to vividly discuss the latest research trends in the field of protein science on Castel Hohenkammer

The 2010 general meeting of the members of CIPSM will take place on the 25th of October at 5 p.m. in the Willstätter lecture room in Großhadern. Give your feelings a vote!

The CIPSM Conference 2010 will be kicked off in beautiful Wildbad Kreuth on the 27th of September. During this conference CIPSM researchers will find time to vividly discuss the latest research trends in the field of protein science.

The LMU-Harvard Young Scientists’ Forum (YSF), represented by MCN and CIPSM, seeks to unite Ph.D. students and postdoctoral fellows from the Harvard University and the Ludwig-Maximilians-Universität (LMU) with core faculty from the two universities to create a framework for an interdisciplinary exchange of ideas. This year’s conference will be held at ...

CIPSM sponsored "International Symposium of Synthetic Biology". Although genetically identical, bacterial populations exhibit an extremely heterogeneous life style. New research results indicate that prokaryotic communities have a social behaviour including communication, cooperation, division of labour, cheating, and altruism. During the symposium, the ...

CIPSM-Excursion to the Bayer AG as part of the lecture on Innovations Management of Bayer AGs Board of Management Member Wolfgang Plischke.

The CIPSM Summer School 2010 will be held in Salzburg from June 27th to 29th. Be there or be square!

CIPSM organizes and sponsors the 2010 EMBO Conference "Gene transcription in yeast" held in San Feliu de Guixols in Spain from the 19th to the 24th of June 2010.

CIPSM-Excursion to Bayer Schering Pharma as part of our graduate education series.

CIPSM welcomes you to the CIPSM-Lecture of Prof. Dr. Julius Rebek (The Scripps Research Institute, La Jolla, USA) entiteled “Molecular Behavior in Small Spaces” on Montag, April 26st 2010 at 17.00 s.t. at the TUM Department of Chemistry in Garching (room: HS22210).

CIPSM sponsors the "Alpenforum 2010" which will hit Oberammergau from16th to 18th April 2010! The event is dedicated to straighten contacts between young chemists and companies. Be there or be square!

CIPSM sponsors the Chromatin Proteomics Workshop which will take place at the LMU in Munich from the 23rd to 24th of March 2010! The large diversity of cell types and associated functions in multicellular organisms arises through complex molecular, biochemical and cellular processes in cellular differentiation. Whereas genetic information is stored in a ...

The Ringberg Symposium on Neurodegeneration in Zebrafish will be kicked off 2010 in the beautiful Castle Ringberg near lake Tegernsee on the 21st of February. We thank CIPSM's Bettina Schmid and Christian Haass for the organisation! The Collaborative Research Center Molecular Mechanisms of Neurodegeneration of the German Research Council (DFG) organizes ...

Die Vorlesung umfasst 4 Blöcke a zwei Doppelstunden inkl. Diskussion im WS 2009/10 und richtet sich an Studentinnen/en im Hauptsstudium und Doktorandinnen/en aller Fachrichtungen. Daten: 23. November 2009, 16. Dezember 2009, 15. Januar 2010 und 25. Januar 2010 jeweils von 13:00-17:00 im Baeyer-Hörsaal, Department Chemie & Biochemie der LMU, Butenandtstr. ...

The CIPSM Irsee Conference will be kicked off 2009 in the beautiful Monastery of Irsee on the 11th of October. During this conference CIPSM and Bayer Schering Pharma researchers will find time to vividly discuss the latest research trends in the field of protein science.

CIPSM welcomes you to the CIPSM-Lecture of Prof. Dr. Martina Havenith (Physikalische Chemie II der Ruhr-Universität Bochum) entiteled “Understanding solvation and the interplay between fluctuation and function: The THz dance of the water with the protein” on Montag, July 13th 2009 at 16.00 c.t. at the TUM Department of Chemistry in Garching.

CIPSM sponsors the "Alpenforum 2009" which will rock Oberammergau from 26.-28. of June 2009! The event is dedicated to straighten contacts between young chemists and companies. Be there or be square!

The LMU-Harvard Young Scientists’ Forum (YSF), represented by MCN and CIPSM, seeks to unite Ph.D. students and postdoctoral fellows from the Harvard University and the Ludwig-Maximilians-Universität (LMU) with core faculty from the two universities to create a framework for an interdisciplinary exchange of ideas. This year’s conference entiteled "From ...

Die Wissenschaftlerinnen der Fächer Chemie, Biochemie und Pharmazie freuen sich am 16. Juni 2009 um 17:00 im Butenandt-Hörsaal an der Fakultät Chemie und Pharmazie der LMU in Großhadern auf einen intensiven Austausch mit den Studierenden.

The CIPSM-Nachwuchs-Minisymposium will be held on the 25th of March 2009 at the Chemistry Department of the TUM in Garching.

The CIPSM "Synthesefest" will celebrate organic chemistry on the 17th to 18th of March 2009 in the Buchner Auditorium. Be organic or be square!