Research Area A

2013

  Uptake Kinetics and Nanotoxicity of Silica Nanoparticles Are Cell Type Dependent
  Targeted Drug Delivery in Cancer Cells with Red-Light Photoactivated Mesoporous Silica Nanoparticles
  A fast analysis method to quantify nanoparticle uptake on a single cell level

2012

  Controlling The Mobility Of Oligonucleotides In The Nanochannels Of Mesoporous Silica
  Rapid Folding of DNA into Nanoscale Shapes at Constant Temperature
  Cryo-EM structure of a 3D DNA-origami object
  Synthetic Lipid Membrane Channels Formed by Designed DNA Nanostructures
  Enhanced Bioactivity of Internally Functionalized Cationic Dendrimers with PEG Cores
  Magnesium-free self-assembly of multi-layer DNA objects
  Release pathways of interferon α2a molecules from lipid twin screw extrudates revealed by single molecule fluorescence microscopy
  Amyloid-Like Structures Formed by Azobenzene Peptides: Light-Triggered Disassembly
  Dynamics of ultraviolet-induced DNA lesions: Dewar formation guided by pre-tension induced by the backbone
  Tuning Nanoparticle Uptake: Live-Cell Imaging Reveals Two Distinct Endocytosis Mechanisms Mediated by Natural and Artificial EGFR Targeting Ligand
  ONIOM approach for non-adiabatic on-the-fly molecular dynamics demonstrated for the backbone controlled Dewar valence isomerization
  Cascaded Photoinduced Drug Delivery to Cells from Multifunctional Core–Shell Mesoporous Silica
  DNA Origami Gatekeepers for Solid-State Nanopores
  Light-Switchable Hemithioindigo–Hemistilbene-Containing Peptides: Ultrafast Spectroscopy of the Z → E Isomerization of the Chromophore and the Structural Dynamics of the Peptide Moiety
  Direct Visualization of Dye and Oligonucleotide Diffusion in Silica Filaments with Collinear Mesopores
  Mechanism of UV-Induced Formation of Dewar Lesions in DNA
  Heat shock protein 90’s mechanochemical cycle is dominated by thermal fluctuations

2011

  Direct Visualization of Dye and Oligonucleotide Diffusion in Silica Filaments with Collinear Mesopores
  Quantitative prediction of 3D solution shape and flexibility of nucleic acid nanostructures
  How kinesin-2 forms a stalk
  The Complex Folding Network of Single Calmodulin Molecules
  Controlling The Mobility Of Oligonucleotides In The Nanochannels Of Mesoporous Silica
  Fast-folding α-helices as reversible strain absorbers in the muscle protein myomesin
  Effect of integrin targeting and PEG shielding on polyplex micelle internalization 2 studied by live-cell imaging
  The Initiation Factor TFE and the Elongation Factor Spt4/5 Compete for the RNAP Clamp during Transcription Initiation and Elongation
  The Excited-State Decay of 1-Methyl-2(1H)-pyrimidinone is an Activated Process
  Single-particle Tracking as a Quantitative Microscopy-based Approach to Unravel Cell Entry Mechanisms of Viruses and Pharmaceutical Nanoparticles
  The complexity of mesoporous silica nanomaterials unravelled by single molecule microscopy
  Regulatory Posttranslational Modifications in Hsp90 Can Be Compensated by Cochaperone Aha1
  Vibrational Spectra of the Ground and the Singlet Excited ππ* State of 6,7-Dimethyl-8-ribityllumazine
  Live-cell visualization of dynamics of HIV budding site interactions with an ESCRT component
  Nitro-Phenylalanine: A Novel Sensor for Heat Transfer in Peptides
  Light-Triggered Aggregation and Disassembly of Amyloid-Like Structures
  A primer to scaffolded DNA origami
  Substrate discrimination of the chaperone BiP by autonomous and cochaperone-regulated conformational transitions
  Visualization of the self-assembly of silica nanochannels reveals growth mechanism
  Folding and Unfolding of Light-Triggered beta-Hairpin Model Peptides

2010

  Photophysics of New Photostable Rylene Derivatives: Applications in Single-Molecule Studies and Membrane Labelling
  Molecular Driving Forces for Z/E Isomerization Mediated by Heteroatoms: The Example Hemithioindigo
  Reporters in the nanoworld: diffusion of single molecules in mesoporous materials
  Controlling the Structure of Proteins at Surfaces
  Perylene-Labeled Silica Nanoparticles: Synthesis and Characterization of Three Novel Silica Nanoparticle Species for Live-Cell Imaging
  Bio-inspired novel design principles for artificial molecular motors
  Dynamics of heat shock protein 90 C-terminal dimerization is an important part of its conformational cycle
  Role of Endosomal Escape for Disulfide-Based Drug Delivery from Colloidal Mesoporous Silica Evaluated by Live-Cell Imaging
  Structural and Mechanical Hierarchies in the Alpha Crystallin Domain Dimer of the Hyperthermophilic Small Heat Shock Protein Hsp16.5
  Chaperonin-Catalyzed Rescue of Kinetically Trapped States in Protein Folding
  DNA photodamage: Study of cyclobutane pyrimidine dimer fornlation il1 a locked thymine dinucleotide
  Tautomerization of 2-nitroso-N-arylanilines by coordination as N,N′-chelate ligands to rhenium(I) complexes and the anticancer activity of newly synthesized oximine rhenium(I) complexes against human melanoma and leukemia cells in vitro
  Pulling a Single Polymer Molecule off a Substrate Reveals the Binding Thermodynamics of Cosolutes
  Colchicine-Loaded Lipid Bilayer-Coated 50 nm Mesoporous Nanoparticles Efficiently Induce Microtubule Depolymerization upon Cell Uptake
  CIPSM-Professor Jens Michaelis receives the 2010 Nernst-Haber-Bodenstein Prize
  Regulation of a heterodimeric kinesin-2 through an unprocessive motor domain that is turned processive by its partner
  Novel detection scheme for application in pump–repump–probe spectroscopy
  Relaxation time prediction for a light switchable peptide by molecular dynamics
  Increasing the efficiency of the ring-opening reaction of photochromic indolylfulgides by optical pre-excitation
  The Conformational Dynamics of the Mitochondrial Hsp70 Chaperone
  Aging of Hydrogenated and Oxidized Diamond
  Exploring the Conformation-Regulated Function of Titin Kinase by Mechanical Pump and Probe Experiments with Single Molecules

2009

  Polymer Adhesion at the Solid–Liquid Interface Probed by a Single–Molecule Force Sensor
  The detailed balance limit of photochemical energy conversion
  Single Molecule Adhesion Mechanics on Rough Surfaces
  Visualizing Single-Molecule Diffusion in Nanochannel Systems
  Adsorption Mechanism of Polypeptides and Their Location at Hydrophobic Interfaces
  Dynamics of HIV-1 Assembly and Release
  DNA based molecular motors
  YEAH! CIPSM-Professor Jens Michaleis receives big €-EU-Grant
  A 75 MHz Light Source for Femtosecond Stimulated Raman Microscopy
  Disturbing interference patterns in femtosecond stimulated Raman microscopy
  Photochemistry with thermal versus optical excess energy: Ultrafast cycloreversion of indolylfulgides and indolylfulgimides
  Real-time Nanomicroscopy via Three-Dimensional Single-Particle Tracking
  Single-molecule force spectroscopy distinguishes target binding modes of calmodulin
  Folding DNA into Twisted and Curved Nanoscale Shapes
  Stability and reaction dynamics of trifluorinated indolylfulgides
  The titin-telethonin complex is a directed, superstable molecular bond in the muscle Z-disk
  Nano positioning system reveals the course of upstream and nontemplate DNA within the RNA polymerase II elongation complex
  Influence of the Charge at D85 on the Initial Steps in the Photocycle of Bacteriorhodopsin
  Nanostructured Silica Materials As Drug-Delivery Systems for Doxorubicin: Single Molecule and Cellular Studies
  Single molecule force measurements delineate salt, pH and surface effects on biopolymer adhesion
  Dynamics of magnetic lipoplexes studied by single particle tracking in living cells
  Atomic force microscopy spring constant determination in viscous liquids
  Thymine Dimerization in DNA Model Systems: Cyclobutane Photolesion Is Predominantly Formed via the Singlet Channel
  Single-Molecule Investigations of a Photoswitchable Nanodevice
  The large conformational changes of Hsp90 are only weakly coupled to ATP hydrolysis
  Mutations of the peripheral antenna complex LH2–correlations of energy transfer time with other functional properties
  Wavelength and solvent independent photochemistry: the electrocyclic ring-closure of indolylfulgides
  Ligand-Dependent Equilibrium Fluctuations of Single Calmodulin Molecules
  Photochromic Bis(thiophen-3-yl)maleimides Studied with Time-Resolved Spectroscopy
  Ultrafast Hemithioindigo-based peptide-switches

2008

  Photophysics of New Water-Soluble Terrylenediimide Derivatives and Applications in Biology
  Accelerated and Efficient Photochemistry from Higher Excited Electronic States in Fulgide Molecules
  Design criteria for optimal photosynthetic energy conversion
  A nano-positioning system for macromolecular structural analysis
  Nanoparticle Self-Assembly on a DNA-Scaffold Written by Single-Molecule Cut-and-Paste
  Mechanoenzymatics of titin kinase
  Dynamics of photoinduced endosomal release of polyplexes
  Simultaneous Transport of Different Localized mRNA Species Revealed by Live-Cell Imaging
  Monitoring Protein Conformation along the Pathway of Chaperonin-Assisted Folding
  Chemical control of Hemithioindigo-photoisomerization – Substituent-effects on different molecular parts
  PIE: eine multidimensionale Fluoreszenzmethode
  Hydrophobic and Hofmeister Effects on the Adhesion of Spider Silk Proteins onto Solid Substrates: An AFM-Based Single-Molecule Study
  Conformational changes of a Swi2/Snf2 ATPase during its mechano-chemical cycle
  Single Molecule Fluorescence of Native and Refolded Peridinin–Chlorophyll–Protein Complexes
  Single-molecule tracking of mRNA exiting from RNA polymerase II
  The Hammett Relationship and Reactions in the Excited Electronic State Hemithioindigo Z/E-Photoisomerization

2007

  Solarzellen nach biologischem Vorbild?
  Metal-Enhanced Fluorescence of Chlorophylls in Single Light-Harvesting Complexes
  Revealing the bifurcation in the unfolding pathways of GFP by using single-molecule experiments and simulations
  Visualizing single-molecule diffusion in mesoporous materials
  Relative binding affinities of chlorophylls in peridinin–chlorophyll–protein reconstituted with heterochlorophyllous mixtures
  Light-triggered beta-hairpin folding and unfolding
  Direct Observation of Active Protein Folding Using Lock-in Force Spectroscopy
  Infrared Studies of Small Azobenzene Peptides: Unexpectedly Slow Reactions on the Time Range of Minutes
  Photochemical Z to E Isomerization of a Hemithioindigo/Hemistilbene omega-Amino Acid
  Comparing a Photoinduced Pericyclic Ring Opening and Closure: Differences in the Excited State Pathways
  Dem Molekül auf der Spur
  Femtosecond stimulated Raman microscopy
  Experimental Test of Connector Rotation during DNA Packaging into Bacteriophage Phi29 Capsids




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LMUexcellent
TU München
MPG
Helmholz Muenchen
MPI of Neurobiology
MPI of Biochemistry