Research Area B

2013

  Structures of the human and Drosophila 80S ribosome
  Structural and Functional Analysis of the DEAF-1 and BS69 MYND Domains
  The Regulatory Domain Stabilizes the p53 Tetramer by Intersubunit Contacts with the DNA Binding Domain

2012

  Folding of large multidomain proteins by partial encapsulation in the chaperonin TRiC/CCT
  Arabidopsis thaliana Oxa proteins locate to mitochondria and fulfill essential roles during embryo development
  Characterization of Enzymes from Legionella pneumophila Involved in Reversible Adenylylation of Rab1 Protein
  Nucleus-Encoded Light-Harvesting Chlorophyll a/b Proteins are Imported Normally into Chlorophyll b-free Chloroplasts of Arabidopsis
  The first alpha-helical domain of the vesicle-inducing protein in plastids 1 promotes oligomerization and lipid binding
  Essential Role of VIPP1 in Chloroplast Envelope Maintenance in Arabidopsis
  AtTPR7 is a chaperone-docking protein of the Sec translocon in Arabidopsis
  Posttranslational modifications of Rab proteins cause effective displacement of GDP dissociation inhibitor
  Depletion of leaf-type ferredoxin-NADP+ oxidoreductase results in the permanent induction of photoprotective mechanisms in Arabidopsis chloroplasts
  Conformational Switching of the Molecular Chaperone Hsp90 via Regulated Phosphorylation
  Identification of a Hypochlorite-specific Transcription Factor from Escherichia coli
  Programmed cell death in Ricinus and Arabidopsis: the function of KDEL cysteine peptidases in development
  Reversible phosphocholination of Rab proteins by Legionella pneumophila effector proteins
  Chloroplast-localized protein kinases: a step forward towards a complete inventory
  The role of calcium in chloroplasts—an intriguing and unresolved puzzle
  The architecture of functional modules in the Hsp90 co-chaperone Sti1/Hop
  A toolset of aequorin expression vectors for in planta studies of subcellular calcium concentrations in Arabidopsis thaliana

2011

  The phosphorylation state of chloroplast transit peptides regulates preprotein import
  The plastid outer envelope protein OEP16 affects metabolic fluxes during ABA-controlled seed development and germination
  The Arabidopsis calmodulin-like proteins AtCML30 and AtCML3 are targeted to mitochondria and peroxisomes, respectively
  How kinesin-2 forms a stalk
  Vibralactone as a Tool to Study the Activity and Structure of the ClpP1P2 Complex from Listeria monocytogenes
  Arabidopsis calcium-binding mitochondrial carrier proteins as potential facilitators of mitochondrial ATP-import and plastid SAM-import
  Firefly luciferase mutants as sensors of proteome stress
  Structural analysis of the interaction between Hsp90 and the tumor suppressor protein p53
  The Cytosolic Kinases STY8, STY17, and STY46 Are Involved in Chloroplast Differentiation in Arabidopsis
  Protein Import into Chloroplasts: Dealing with the (Membrane) Integration Problem
  Cytosolic HSP90 Cochaperones HOP and FKBP Interact with Freshly Synthesized Chloroplast Preproteins of Arabidopsis
  Technical note: Brassica rapa: a new model plant for the isolation of chloro-plasts and biochemical studies
  Total Chemical Synthesis of an Integral Membrane Enzyme: Diacylglycerol Kinase from Escherichia coli
  Closing In on the Hsp90 Chaperone-Client Relationship
  Mapping backbone and side-chain interactions in the transition state of a coupled protein folding and binding reaction
  Protein disulfide isomerase isomerizes non-native disulfide bonds in human proinsulin independent of its peptidebinding activity
  Reduction of disulphide bonds unmasks potent antimicrobial activity of human Beta-defensin 1
  Substrate discrimination of the chaperone BiP by autonomous and cochaperone-regulated conformational transitions

2010

  Approaching the Secrets of N-Glycosylation in Aspergillus fumigatus: Characterization of the AfOch1 Protein
  Mixed Hsp90–cochaperone complexes are important for the progression of the reaction cycle
  Ferredoxin:NADPH oxidoreductase is recruited to thylakoids by binding to a polyproline type II helix in a pH-dependent manner
  The Heat Shock Response: Life on the Verge of Death
  Protein import into chloroplasts—How chaperones feature into the game
  Hsp12 Is an Intrinsically Unstructured Stress Protein that Folds upon Membrane Association and Modulates Membrane Function
  Dynamics of heat shock protein 90 C-terminal dimerization is an important part of its conformational cycle
  Structure of hibernating ribosomes studied by cryoelectron tomography in vitro and in situ
  A new concept for ferredoxin–NADP(H) oxidoreductase binding to plant thylakoids
  Redox extends its regulatory reach to chloroplast protein import
  Structural and Mechanical Hierarchies in the Alpha Crystallin Domain Dimer of the Hyperthermophilic Small Heat Shock Protein Hsp16.5
  NETs formed by human neutrophils inhibit growth of the pathogenic mold Aspergillus fumigatus
  Chaperonin-Catalyzed Rescue of Kinetically Trapped States in Protein Folding
  Dissecting the Alternatively Folded State of the Antibody Fab Fragment
  The plant PRAT proteins – preprotein and amino acid transport in mitochondria and chloroplasts
  Intramembrane Proteolysis of Mgm1 by the Mitochondrial Rhomboid Protease Is Highly Promiscuous Regarding the Sequence of the Cleaved Hydrophobic Segment
  Independent evolution of the core domain and its flanking sequences in small heat shock proteins
  Farnesol misplaces tip-localized Rho proteins and inhibits cell wall integrity signalling in Aspergillus fumigatus
  AfMkk2 is required for cell wall integrity signaling, adhesion, and full virulence of the human pathogen Aspergillus fumigatus
  Evolution of Escherichia coli for growth at high temperatures
  The Conformational Dynamics of the Mitochondrial Hsp70 Chaperone
  An unlocking/relocking barrier in conformational fluctuations of villin headpiece subdomain
  Regions Outside the Alpha-Crystallin Domain of the Small Heat Shock Protein Hsp26 Are Required for Its Dimerization
  Asymmetric Activation of the Hsp90 Dimer by Its Cochaperone Aha1
  Redox-regulation of protein import into chloroplasts and mitochondria: Similarities and differences.
  The many faces of the mitochondrial TIM23 complex
  Protein import into chloroplasts: The Tic complex and its regulation
  Coupled chaperone action in folding and assembly of hexadecameric Rubisco
  A coronin7 homolog with functions in actin-driven processes
  Role of Tim50 in the Transfer of Precursor Proteins from the Outer to the Inner Membrane of Mitochondria

2009

  How antibodies fold
  ATPase domain and interdomain linker play a key role in aggregation of mitochondrial Hsp70 chaperone Ssc1
  Superior Protective Immunity against Murine Listeriosis by Combined Vaccination with CpG DNA and Recombinant Salmonella enterica Serovar Typhimurium
  Alb4 of Arabidopsis Promotes Assembly and Stabilization of a Non Chlorophyll-Binding Photosynthetic Complex, the CF1CF0–ATP Synthase
  The mitA gene of Aspergillus fumigatus is required for mannosylation of inositol-phosphorylceramide, but is dispensable for pathogenicity
  The Folding Pathway of the Antibody VL Domain
  The charged linker region is an important regulator of Hsp90 function
  Arabidopsis Tic62 and Ferredoxin-NADP(H) Oxidoreductase Form Light-Regulated Complexes That Are Integrated into the Chloroplast Redox Poise
  Arabidopsis OBG-Like GTPase (AtOBGL) Is Localized in Chloroplasts and Has an Essential Function in Embryo Development
  Calcium regulation in endosymbiotic organelles of plants
  Formation of She2p tetramers is required for mRNA binding, mRNP assembly, and localization
  Hsp90 is regulated by a switch point in the C-terminal domain
  Structural and functional diversity in the family of small heat shock proteins from the parasite Toxoplasma gondii
  NMR Structure of a Monomeric Intermediate on the Evolutionarily Optimized Assembly Pathway of a Small Trimerization Domain
  The eye lens chaperone alpha-crystallin forms defined globular assemblies
  Distinct roles of the two isoforms of the dynamin-like GTPase Mgm1 in mitochondrial fusion
  Preprotein Import into Chloroplasts via the Toc and Tic Complexes Is Regulated by Redox Signals in Pisum sativum
  Arabidopsis ATPase family gene 1-like protein 1 is a calmodulin-binding AAA+-ATPase with a dual localization in chloroplasts and mitochondria
  A search for factors influencing etioplast - chloroplast transition
  Formation of cristae and crista junctions in mitochondria depends on antagonism between Fcj1 and Su e/g
  An Unfolded CH1 Domain Controls the Assembly and Secretion of IgG Antibodies
  Graduate School Life Science Munich (LSM)
  Interaction of human heat shock protein 70 with tumor-associated peptides
  The large conformational changes of Hsp90 are only weakly coupled to ATP hydrolysis
  Rapid Matrix-Assisted Refolding of Histidine-Tagged Proteins
  Dissection of the ATP-induced conformational cycle of the molecular chaperone Hsp90
  Calcium depletion and calmodulin inhibition affect the import of nuclear-encoded proteins into plant mitochondria
  Protein import machineries in endosymbiotic organelles
  Protein transport in organelles: The composition, function and regulation of the Tic complex in chloroplast protein import
  The Native 3D Organization of Bacterial Polysomes
  Role of Tim50 in the Transfer of Precursor Proteins from the Outer to the Inner Membrane of Mitochondria
  Local conformational dynamics in alpha-helices measured by fast triplet transfer

2008

  Interaction of tim23 with tim50 is essential for protein translocation by the mitochondrial tim23 complex
  Characterization of TIC110, a channel-forming protein at the inner envelope membrane of chloroplasts, unveils a response to Ca2+ and a stromal regulatory disulfide bridge
  Semisynthesis of a Glycosylphosphatidylinositol-Anchored Prion Protein
  Import of preproteins into the chloroplast inner envelope membran
  Rheology
  Thirty years of protein translocation into mitochondria: Unexpectedly complex and still puzzling
  The Actinome of Dictyostelium discoideum in Comparison to Actins and Actin-Related Proteins from Other Organisms
  The structure of a folding intermediate provides insight into differences in immunoglobulin amyloidogenicity
  Effect of Thioxopeptide Bonds on r-Helix Structure and Stability
  Active remodelling of the TIM23 complex during translocation of preproteins into mitochondria
  Contribution of Trimeric Autotransporter C-Terminal Domains of Oligomeric Coiled-Coil Adhesin (Oca) Family Members YadA, UspA1, EibA, and Hia to Translocation of the YadA Passenger Domain and Virulence of Yersinia enterocolitica
  Actin: its cumbersome pilgrimage through cellular compartments
  Energetics of protein translocation into mitochondria
  Unusual, Virulence Plasmid-Dependent Growth Behavior of Yersinia enterocolitica in Three-Dimensional Collagen Gels
  Monitoring Protein Conformation along the Pathway of Chaperonin-Assisted Folding
  TIC62 Redox-regulated Translocon Composition and Dynamics
  Structural Dynamics of Archaeal Small Heat Shock Proteins
  Activation of the Chaperone Hsp26 is Controlled by the Rearrangement of Its Thermosensor Domain

2007

  Properties of the Kinesin-1 motor DdKif3 from Dictyostelium discoideum
  A step dissected
  A Grp on the Hsp90 Mechanism
  The ATP-ase cycle of the endoplamic chaperone GRP94
  Protein transport in chloroplasts - targeting to the intermembrane space




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LMUexcellent
TU München
MPG
Helmholz Muenchen
MPI of Neurobiology
MPI of Biochemistry