Research Area C

2010

  Interplay between the Ribosomal Tunnel, Nascent Chain, and Macrolides Influences Drug Inhibition
  Nucleocytoplasmic shuttling of the La motif-containing protein Sro9 might link its nuclear and cytoplasmic functions
  A conserved spider silk domain acts as a molecular switch that controls fibre assembly
  The Impact of Amino Acid Side Chain Mutations in Conformational Design of Peptides and Proteins
  Cell Adhesion Strength Is Controlled by Intermolecular Spacing of Adhesion Receptors
  Asymmetric Activation of the Hsp90 Dimer by Its Cochaperone Aha1
  An Efficient Protocol for NMR-Spectroscopy-Based Structure Determination of Protein Complexes in Solution
  BclxL Changes Conformation upon Binding to Wild-type but Not Mutant p53 DNA Binding Domain
  Coupled chaperone action in folding and assembly of hexadecameric Rubisco
  Imaging of integrin avb3 expression in patients with malignant glioma by [18F] Galacto-RGD positron emission tomography
  The Transmembrane Structure of Integrin aIIbb3: Significance for Signal Transduction

2009

  Modulation of protein properties in living cells using nanobodies
  Structural Insight into Nascent Polypeptide Chain–Mediated Translational Stalling
  Structure of Monomeric Yeast and Mammalian Sec61 Complexes Interacting with the Translating Ribosome
  The A–Z of bacterial translation inhibitors
  Biosynthesis of the Aminocyclitol Subunit of Hygromycin A in Streptomyces hygroscopicus NRRL 2388
  Identification of Distinct Thiopeptide-Antibiotic Precursor Lead Compounds Using Translation Machinery Assays
  X-ray structure of Pur-α reveals a Whirly-like fold and an unusual nucleic-acid binding surface
  Lessons from structural and biochemical studies on the archaeal exosome
  Enhanced SnapShot: Antibiotic Inhibition of Protein Synthesis II
  DNA Double-Strand Breaks Come into Focus
  A Boost for Sequence Searching
  SnapShot: Antibiotic Inhibition of Protein Synthesis I
  The torpedo nuclease Rat1 is insufficient to terminate RNA polymerase II in vitro
  Molecular basis of transcriptional mutagenesis at 8-oxoguanine
  The Final Step of Hygromycin A Biosynthesis, Oxidation of C-5''-Dihydrohygromycin A, Is Linked to a Putative Proton Gradient-Dependent Efflux
  Formation of She2p tetramers is required for mRNA binding, mRNP assembly, and localization
  Endo-siRNAs depend on a new isoform of loquacious and target artificially introduced, high-copy sequences
  Helical Growth of the Arabidopsis Mutant tortifolia2 Does Not Depend on Cell Division Patterns but Involves Handed Twisting of Isolated Cells
  mRNA Export - An Integrative Component of Gene Expression
  Nano positioning system reveals the course of upstream and nontemplate DNA within the RNA polymerase II elongation complex
  Mutations affecting the secretory COPII coat component SEC23B cause congenital dyserythropoietic anemia type II
  Structural Basis of Transcription: Mismatch-Specific Fidelity Mechanisms and Paused RNA Polymerase II with Frayed RNA
  Unusual bipartite mode of interaction between the nonsense-mediated decay factors, UPF1 and UPF2.
  Fast and accurate automatic structure prediction with HHpred
  An Unfolded CH1 Domain Controls the Assembly and Secretion of IgG Antibodies
  Adhesion Dance with Raver
  Ligands for Mapping αvβ3-Integrin Expression in Vivo
  Breaking the Dogma of the Metal-Coordinating Carboxylate Group in Integrin Ligands: Introducing Hydroxamic Acids to the MIDAS To Tune Potency and Selectivity
  A movie of the RNA polymerase nucleotide addition cycle
  Structure and in Vivo Requirement of the Yeast Spt6 SH2 Domain
  HHomp—prediction and classification of outer membrane proteins
  Non-Hydrolyzable RNA-Peptide Conjugates: A Powerful Advance in the Synthesis of Mimics for 3-Peptidyl tRNA Termini
  The HSP90 binding mode of a radicicol-like E-oxime determined by docking, binding free energy estimations, and NMR 15N chemical shifts
  Interaction of human heat shock protein 70 with tumor-associated peptides
  Sequence context-specific profiles for homology searching
  Cytosolic Viral Sensor RIG-I Is a 5′-Triphosphate–Dependent Translocase on Double-Stranded RNA
  Structure and Ligand Binding of the Extended Tudor Domain of D. melanogaster Tudor-SN
  Impact of Order and Disorder in RGD Nanopatterns on Cell Adhesion
  The regulatory domain of the RIG-I family ATPase LGP2 senses double-stranded RNA
  Structural basis for competitive interactions of Pex14 with the import receptors Pex5 and Pex19
  Structure–function studies of the RNA polymerase II elongation complex
  Less Is More for Leaderless mRNA Translation
  Time-Resolved Binding of Azithromycin to Escherichia coli Ribosomes
  The Native 3D Organization of Bacterial Polysomes
  A Distinct Mode of Interaction of a Novel Ketolide Antibiotic That Displays Enhanced Antimicrobial Activity
  Thioredoxin as a fusion tag for carrier-driven crystallization

2008

  MicroRNAs Repress Mainly through mRNA Decay
  RNA polymerase fidelity and transcriptional proofreading
  The archaeal RNA polymerase subunit P and the eukaryotic polymerase subunit Rpb12 are interchangeable in vivo and in vitro
  Cooperativity in Adhesion Cluster Formation during Initial Cell Adhesion
  Phospholipid scramblases and Tubby-like proteins belong to a new superfamily of membrane tethered transcription factors
  Cell interactions with hierarchically structured nano-patterned adhesive surfaces
  A NMR strategy to unambiguously distinguish nucleic acid hairpin and duplex conformations applied to a Xist RNA A-repeat
  Can N-methylated amino acids serve as substitutes for prolines in conformational design of cyclic pentapeptides?
  Structure of the intracellular domain of the amyloid precursor protein in complex with Fe65-PTB2
  Dimerization and Protein Binding Specificity of the U2AF Homology Motif of the Splicing Factor Puf60*
  The Solution Structure of BMPR-IA Reveals a Local Disorder-to-Order Transition upon BMP-2 Binding
  Ulrike Gaul comes to CIPSM! Germany, Munich – the house is rocking.
  Screening of fusion partners for high yield expression and purification of bioactive viscotoxins
  Deuterated polymer gels for measuring anisotropic NMR parameters with strongly reduced artefacts
  The oxazolidinone antibiotics perturb the ribosomal peptidyl-transferase center and effect tRNA positioning
  Perspectives on NMR in drug discovery: a technique comes of age
  CIPSM Coordinator Horst Kessler wins Josef Rudinger Award
  YEAH! CIPSM-Junior-Group Leader Katja Strässer receives big €-EU-Grant
  A new tRNA intermediate revealed on the ribosome during EF4-mediated back-translocation
  A structure refinement protocol combining NMR residual dipolar couplings and small angle scattering restraints
  Backbone assignment of the UHM domain of Puf60 free and bound to five ligands
  N-Methylation of Peptides: A New Perspective in Medicinal Chemistry
  The structure of a folding intermediate provides insight into differences in immunoglobulin amyloidogenicity
  Induction of Cell Polarization and Migration by a Gradient of Nanoscale Variations in Adhesive Ligand Spacing
  Rational Design of Highly Active and Selective Ligands for the alpha-5-beta-1 Integrin Receptor
  The Role of 23S Ribosomal RNA Residue A2451 in Peptide Bond Synthesis Revealed by Atomic Mutagenesis
  Isothiocyanate-functionalized RGD peptides for tailoring cell-adhesive surface patterns
  The sweetest candy for the virus
  Introduction of Functional Groups into Peptides via N-Alkylation
  Translational Regulation via L11: Molecular Switches on the Ribosome Turned On and Off by Thiostrepton and Micrococcin
  1H, 13C, and 15N chemical shift assignments for the Eps15-EH2-stonin 2 complex
  The CLIP/CLAP-HSQC: Pure absorptive spectra for the measurement of one-bond couplings
  Phosphorus NMR Spectroscopy as a Versatile Tool for Compound Library Screening
  Improving Oral Bioavailability of Peptides by Multiple N-Methylation: Somatostatin Analogues
  Role of Ser-340 and Thr-341 in Transmembrane Domain IX of the Na+/Proline Transporter PutP of Escherichia coli in Ligand Binding Transport
  Conformational Preference and Potential Templates of N-Methylated Cyclic Pentaalanine Peptides
  Assessment of αvβ3 Integrin Expression after Myocarcdial Infarction by Positron Emission Tomography
  The C-Terminal Regulatory Domain Is the RNA 5`-Triphosphate Sensor of RIG-I
  Structure of the Eps15–stonin2 complex provides a molecular explanation for EH-domain ligand specificity
  Efficient factor VIII affinity purification using a small synthetic ligand
  Single-molecule tracking of mRNA exiting from RNA polymerase II

2007

  Functional Architecture of RNA Polymerase I
  The membrane-integrated transcriptional activator CadC of Escherichia coli senses lysine indirectly via the interaction with the lysine permease LysP
  2008 Gottfried Wilhelm Leibniz Prize for CIPSM researcher Elena Conti
  Cryo-EM study of the spinach chloroplast ribosome reveals the structural and functional roles of plastid-specific ribosomal proteins
  Molecular basis of RNA-dependent RNA polymerase II activity
  Allowing an elite
  Seeing Cisplatin - Discerning how an anticancer drug meddles with replication, transcription
  Mechanism of transcriptional stalling at cisplatindamaged DNA
  Structural Aspects of RbfA Action during Small Ribosomal Subunit Assembly
  Bypass of DNA Lesions Generated During Anticancer Treatment with Cisplatin by DNA Polymerase Eta
  Multiple N-Methylation by a Designed Approach Enhances Receptor Selectivity
  Archaeal transcription: function of an alternative transcription factor B from Pyrococcus furiosus
  Structural Biology of RNA Polymerase III: Mass Spectrometry Elucidates Subcomplex Architecture
  J-ONLY-TOCSY: Efficient suppression of RDC-induced transfer in homonuclear TOCSY experiments using JESTER-1-derived multiple pulse sequences
  Specific Integrin Labeling in Living Cells Using Functionalized Nanocrystals
  High-Resolution Structure of a Na+/H+ Antiporter Dimer Obtained by Pulsed Electron Paramagnetic Resonance Distance Measurements
  Development of a Peptidomimetic Ligand for Efficient Isolation and Purification of Factor VIII via Affinity Chromatography
  Finding the right spot to start transcription
  Multisubunit RNA Polymerases Melt Only a Single DNA Base Pair Downstream of the Active Site
  Drosophilia microRNAs Are Sorted into Functionally Distinct Argonaute Complexes after Production by Dicer-1
  piRNAs-the ancient hunters of genome invaders
  U2AF-homology motif interactions are required for alternative splicing regulation by SPF45
  The RGD motif in fi bronectin is essential for development but dispensable for fibril assembly
  Structural basis for DNA duplex sepration by a superfamily-2 helicase
  DNA photodamage recognition by RNA polymerase II
  CPD Damage Recognition by Transcribing RNA Polymerase II




LMUexcellent
TU München
MPG
Helmholz Muenchen
MPI of Neurobiology
MPI of Biochemistry