Research Area D

2010

  Chemical-genomic dissection of the CTD code
  The Activation Potential of MOF Is Constrained for Dosage Compensation
  Epigenetic regulation of development by histone lysine methylation
  CIPSM Excursion to Bayer Schering Pharma with Kirsten Jung
  Heterochromatin dysregulation in human diseases
  Phosphorylation of histone H3T6 by PKCbI controls demethylation at histone H3K4
  Replication Stress Interferes with Histone Recycling and Predeposition Marking of New Histones
  Chemotherapeutic drugs inhibit ribosome biogenesis at various levels
  The complexityofthe‘simple’two-component systemKdpD/KdpE in Escherichia coli
  Activation of Melanoma Differentiation-Associated Gene 5 Causes Rapid Involution of the Thymus
  Defects in 18S or 28S rRNA processing activate the p53 pathway
  RNA Polymerase II C-terminal Heptarepeat Domain Ser-7 Phosphorylation Is Established in a Mediator-dependent Fashion

2009

  The multi-domain protein Np95 connects DNA methylation and histone modification
  Modulation of protein properties in living cells using nanobodies
  Interaction of HP1 and Brg1/Brm with the Globular Domain of Histone H3 Is Required for HP1-Mediated Repression
  Superior Protective Immunity against Murine Listeriosis by Combined Vaccination with CpG DNA and Recombinant Salmonella enterica Serovar Typhimurium
  A New Mechanism of Phosphoregulation in Signal Transduction Pathways
  RNAPII CTD SER-7 phosphorylation is established in a mediator-dependent fashion
  Measurement of replication structures at the nanometer scale using super-resolution light microscopy
  CIPSM researcher Prof. Dr. Thomas Cremer is honored by the German Academy of Sciences Leopoldina with the Schleiden Medal
  Np95 interacts with de novo DNA methyltransferases, Dnmt3a and Dnmt3b, and mediates epigenetic silencing of the viral CMV promoter in embryonic stem cells
  Bundesministerium supports CIPSM cooperation of CIPSM Investigators Leonhardt and Schotta
  Revealing the high-resolution three-dimensional network of chromatin and interchromatin space: A novel electron-microscopic approach to reconstructing nuclear architecture
  CIPSM football team rules the cup!
  The regulatory interplay between membrane-integrated sensors and transport proteins in bacteria
  The dosage compensation complex shapes the conformation of the X chromosome in Drosophila
  A Technical Note on Quantum Dots for Multi-Color Fluorescence in situ Hybridization
  Induction Kinetics of a Conditional pH Stress Response System in Escherichia coli
  Proteome-wide prediction of acetylation substrates
  Proapoptotic signaling induced by RIG-I and MDA-5 results in type I interferon–independent apoptosis in human melanoma cells
  Heterogeneity in quorum sensing-regulated bioluminescence of Vibrio harveyi
  Changes of higher order chromatin arrangements during major genome activation in bovine preimplantation embryos
  Domain swapping reveals that the N-terminal domain of the sensor kinase KdpD in Escherichia coli is important for signaling
  CDK9 directs H2B monoubiquitination and controls replication-dependent histone mRNA 3'-end processing
  5'-triphosphate RNA requires base-paired structures to activate antiviral signaling via RIG-I
  DNA Methylation-Mediated Epigenetic Control
  Chromosome shattering: a mitotic catastrophe due to chromosome condensation failure
  Establishment of Histone Modifications after Chromatin Assembly
  The HP1a–CAF1–SetDB1-containing complex provides H3K9me1 for Suv39-mediated K9me3 in pericentric heterochromatin
  MBD4 and MLH1 are required for apoptotic induction in xDNMT1-depleted embryos
  TFIIH Kinase Places Bivalent Marks on the Carboxy-Terminal Domain of RNA Polymerase II
  Stimulation of the potassium sensor KdpD kinase activity by interaction with the phosphotransferase protein IIANtr in Escherichia coli
  Drosophila ISWI Regulates the Association of Histone H1 With Interphase Chromosomes in Vivo
  Nuclear Architecture of Rod Photoreceptor Cells Adapts to Vision in Mammalian Evolution
  Drosophila HP1c Is Regulated by an Auto-Regulatory Feedback Loop through Its Binding Partner Woc
  Synergy between CD26/DPP-IV Inhibition and G-CSF Improves Cardiac Function after Acute Myocardial Infarction
  Active promoters and insulators are marked by the centrosomal protein 190
  How are signals transduced across the cytoplasmic membrane? Transport proteins as transmitter of information
  Spatiotemporal Dynamics of Regulatory Protein Recruitment at DNA Damage Sites
  Dimerization of DNA Methyltransferase 1 Is Mediated by Its Regulatory Domain
  Backbone Structure of Transmembrane Domain IX of the Naþ/Proline Transporter PutP of Escherichia coli
  A versatile non-radioactive assay for DNA methyltransferase activity and DNA binding
  Monomethylation of Lysine 20 on Histone H4 Facilitates Chromatin Maturation

2008

  The Chromosomal High-Affinity Binding Sites for the Drosophila Dosage Compensation Complex
  The Universal Stress Protein UspC Scaffolds the KdpD/KdpE Signaling Cascade of Escherichia coli under Salt Stress
  Recruitment of RNA polymerase II cofactor PC4
  5´-triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma
  Short-term activation induces multifunctional dendritic cells that generate potent antitumor T-cell responses in vivo
  Discontinuous movement of mRNP particles in nucleoplasmic regions devoid of chromatin
  Identifying specific protein interaction partners using quantitative mass spectrometry and bead proteomes
  Camelid immunoglobulins and nanobody technology
  Combined Use of RNAi and Quantitative Proteomics to Study Gene Function in Drosophila
  PR-SET7 and SUV4-20H regulate H4 lysine-20 methylation at imprinting control regions in the mouse
  Function of Transmembrane Domain IX in the Na+/Proline Transporter PutP
  A fluorescent two-hybrid (F2H) assay for direct visualization of protein interactions in living cells
  Uncoupling the replication machinery
  Targeting CpG Oligonucleotides to the Lymph Node by Nanoparticles Elicits Efficient Antitumoral Immunity
  Nuclear transit of the RNA-binding protein She2 is required for translational control of localized ASH1 mRNA
  Subdiffraction Multicolor Imaging of the Nuclear Periphery with 3D Structured Illumination Microscopy
  A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse
  The PHD Domain of Np95 (mUHRF1) Is Involved in Large-Scale Reorganization of Pericentromeric Heterochromatin
  Photorhabdus luminescens genes induced upon insect infection
  Simultaneous Transport of Different Localized mRNA Species Revealed by Live-Cell Imaging
  Molecular evolution of the RNA polymerase II CTD
  Generation and Characterization of a Rat Monoclonal Antibody Specific for Multiple Red Fluorescent Proteins
  Simple generation of site-directed point mutations in the Escherichia coli chromosome using Red®/ET® Recombination
  DNA vaccination efficiently induces antibodies to Nogo-A and does not exacerbate experimental autoimmune encephalomyelitis
  ATP-dependent chromatosome remodeling
  CIPSM-Researcher Heinrich Leonhardt wins Binder-Innovation Award 2008
  DNA sequence and the organization of chromosomal domains
  The nucleolar SUMO-specific protease SENP3 reverses SUMO modification of nucleophosmin and is required for rRNA processing
  Fine Mapping of Posttranslational Modifications of the Linker Histone H1 from Drosophila melanogaster
  Chromatin proteomics and epigenetic regulatory circuits

2007

  Structure-function analysis of the RNA helicase maleless
  Seven Ups the Code
  Transcribing RNA Polymerase II Is Phosphorylated at CTD Residue Serine-7
  Serine-7 of the RNA Polymerase II CTD Is Specifically Required for snRNA Gene Expression
  Probing Intranuclear Environments at the Single-Molecule Level
  NC2 mobilizes TBP on core promoter TATA boxes
  A mutagenesis strategy combining systematic alanine scanning with larger mutations to study protein interactions
  Feedback-regulated poly(ADP-ribosyl)ation by PARP-1 is required for rapid response to DNA damage in living cells
  A Versatile Nanotrap for Biochemical and Functional Studies with Fluorescent Fusion Proteins
  Maintenance of imprinting and nuclear architecture in cycling cells




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TU München
MPG
Helmholz Muenchen
MPI of Neurobiology
MPI of Biochemistry