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CIPSM
Publications
Research Area D
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Research Area D
2013
Cyclin-dependent kinase 9 links RNA Polymerase II transcription to processing of ribosomal RNA
Structures of Drosophila Cryptochrome and Mouse Cryptochrome1 Provide Insight into Circadian Function
Structural basis of histone H2A–H2B recognition by the essential chaperone FACT
Histone H3 Glutathionylation in Proliferating Mammalian Cells Destabilizes Nucleosomal Structure
The neural crest transcription factor Brn3a is expressed in melanoma and required for cell cycle progression and survival
Functional ribosome biogenesis is a prerequisite for p53 destabilisation: impact of chemotherapy on nucleolar functions and RNA metabolism.
Suv4-20h2 mediates chromatin compaction and is important for cohesin recruitment to heterochromatin
In vivo live imaging of RNA polymerase II transcription factories in primary cells
TLR Activation Excludes Circulating Naive CD8+ T Cells from Gut-Associated Lymphoid Organs in Mice
H3K56me3 Is a Novel, Conserved Heterochromatic Mark That Largely but Not Completely Overlaps with H3K9me3 in Both Regulation and Localization
Dynamic Readers for 5-(Hydroxy)Methylcytosine and Its Oxidized Derivatives
Histone H4 Lysine 20 methylation: key player in epigenetic regulation of genomic integrity
Circadian acetylome reveals regulation of mitochondrial metabolic pathways
Therapeutic Efficacy of Bifunctional siRNA Combining TGF-β1 Silencing with RIG-I Activation in Pancreatic Cancer
2012
CTD serine-2 plays a critical role in splicing and termination factor recruitment to RNA polymerase II in vivo
Global DNA Hypomethylation Prevents Consolidation of Differentiation Programs and Allows Reversion to the Embryonic Stem Cell State
Controlling The Mobility Of Oligonucleotides In The Nanochannels Of Mesoporous Silica
Towards a structural understanding of PARP1 activation and related signalling ADP-ribosyl-transferases
Translation Elongation Factor EF-P Alleviates Ribosome Stalling at Polyproline Stretches
Identification of a Target Gene and Activating Stimulus for the YpdA/YpdB Histidine Kinase/Response Regulator System in Escherichia coli
The ATPase domain of ISWI is an autonomous nucleosome remodeling machine
Direct and Dynamic Detection of HIV-1 in Living Cell
Impact of Histone H4 Lysine 20 Methylation on 53BP1 Responses to Chromosomal Double Strand Breaks
Autoinducers Act as Biological Timers in Vibrio harveyi
MSL2 Combines Sensor and Effector Functions in Homeostatic Control of the Drosophila Dosage Compensation Machinery
Protective and Aggravating Effects of Nlrp3 Inflammasome Activation in IBD Models: Influence of Genetic and Environmental Factors
Histone H2A variants in nucleosomes and chromatin: more or less stable?
Step-Wise Assembly, Maturation and Dynamic Behavior of the Human CENP-P/O/R/Q/U Kinetochore Sub- Complex
Deactivation of the E. coli pH Stress Sensor CadC by Cadaverine
Global analysis of genome, transcriptome and proteome reveals the response to aneuploidy in human cells
Tyrosine-1 and threonine-4 phosphorylation marks complete the RNA polymerase II CTD phospho-code
Dynamic phosphorylation patterns of RNA polymerase II CTD during transcription
Myb-binding Protein 1a (Mybbp1a) Regulates Levels and Processing of Pre-ribosomal RNA
Nucleosome Remodeler SNF2L Suppresses Cell Proliferation and Migration and Attenuates Wnt Signaling
CTD Tyrosine Phosphorylation Impairs Termination Factor Recruitment to RNA Polymerase II
A unified phylogeny-based nomenclature for histone variants
First insights into the unexplored two-component system YehU/YehT in Escherichia coli
Phosphorylation by cyclin-dependent kinase-9 controls ubiquitin-conjugating enzyme-2A function
Versatile Toolbox for High Throughput Biochemical and Functional Studies with Fluorescent Fusion Proteins
EMBO welcomes 3 CIPSM scientists as new members
Cascaded Photoinduced Drug Delivery to Cells from Multifunctional Core–Shell Mesoporous Silica
Threonine-4 of mammalian RNA polymerase II CTD is targeted by Polo-like kinase 3 and required for transcriptional elongation
Ultra short and progressive 4sU-tagging reveals key characteristics of RNA processing at nucleotide resolution
H2A.Z.2.2 is an alternatively spliced histone H2A.Z variant that causes severe nucleosome destabilization
Targeted transcriptional activation of silent oct4 pluripotency gene by combining designer TALEs and inhibition of epigenetic modifiers
ATRX-mediated chromatin association of histone variant macroH2A1 regulates a-globin expression
Structure, function and dynamics of nuclear subcompartments
Cytosolic RIG-I–like helicases act as negative regulators of sterile inflammation in the CNS
Polycomb Associates Genome-wide with a Specific RNA Polymerase II Variant, and Regulates Metabolic Genes in ESCs
Dynamic long-range chromatin interactions control Myb proto-oncogene transcription during erythroid development
CENP-C facilitates the recruitment of M18BP1 to centromeric chromatin.
Connecting Threads: Epigenetics and Metabolism
Roles of long, non-coding RNA in chromosome-wide transcription regulation: Lessons from two dosage compensation systems
Cytosolic DNA Triggers Mitochondrial Apoptosis via DNA Damage Signaling Proteins Independently of AIM2 and RNA Polymerase III
2011
Histidine kinases and response regulators in networks
Probing the conformation of the ISWI ATPase domain with genetically encoded photoreactive crosslinkers and mass spectrometry
Engineering antibodies and proteins for molecular in vivo imaging
In breast cancer, a high ratio of tumour-infiltrating intraepithelial CD8+ to FoxP3+ cells is characteristic for the medullary subtype
CD103 is a hallmark of tumor-infiltrating regulatory T cells
Developmental regulation of N-terminal H2B methylation in Drosophila melanogaster
De novo assembly of a PML nuclear subcompartment occurs through multiple pathways and induces telomere elongation
The MOF-containing NSL complex associates globally with housekeeping genes, but activates only a defined subset
Cdc14 phosphatase promotes segregation of telomeres through repression of RNA polymerase II transcription
Suv4-20h Abrogation Enhances Telomere Elongation during Reprogramming and Confers a Higher Tumorigenic Potential to iPS Cells
Regulation of DNA methyltransferase 1 by interactions and modifcations
Proteomic Interrogation of Human Chromatin
Histone hypoacetylation is required to maintain late replication timing of constitutive heterochromatin
Estrogen-Dependent Gene Transcription in Human Breast Cancer Cells Relies upon Proteasome-Dependent Monoubiquitination of Histone H2B
Cooperative DNA and Histone Binding by Uhrf2 Links the Two Major Repressive Epigenetic Pathways
Splicing enhances recruitment of methyltransferase HYPB/Setd2 and methylation of histone H3 Lys36
Stage-Specific Histone Modification Profiles Reveal Global Transitions in the Xenopus Embryonic Epigenome
Wogonin and related natural flavones are inhibitors of CDK9 that induce apoptosis in cancer cells by transcriptional suppression of Mcl-1
Tuning communication fidelity
Transcription initiation platforms and GTF recruitment at tissue-specific enhancers and promoters
Role for hACF1 in the G2/M damage checkpoint
Recognition of 5-Hydroxymethylcytosine by the Uhrf1 SRA Domain
Systemic Cancer Therapy with a Small Molecule Agonist of Toll-like Receptor 7 Can Be Improved by Circumventing TLR Tolerance
The RNA Helicase Rm62 Cooperates with SU(VAR)3-9 to Re-Silence Active Transcription in Drosophila melanogaster
Twists and turns of DNA methylation
Kirsten Jung's program of emphasis on individuality of bacteria gets DFG funding
Detection and function of an intramolecular disulfide bond in the pH-responsive CadC of Escherichia coli
Functional Nuclear Organization of Transcription and DNA Replication
The C-Terminal Domain of RNA Polymerase II Is Modified by Site-Specific Methylation
H3 Lysine 4 Is Acetylated at Active Gene Promoters and Is Regulated by H3 Lysine 4 Methylation
Sequential Establishment of Marks on Soluble Histones H3 and H4
Identification of ArgP and Lrp as Transcriptional Regulators of lysP, the Gene Encoding the Specific Lysine Permease of Escherichia coli
PARG is recruited to DNA damage sites through poly(ADP-ribose)- and PCNA-dependent mechanisms
Global Analysis of the Relationship between JIL-1 Kinase and Transcription
Kirsten Jung Interview about CIPSMs Gender Equality Program
Characterization of PvuRts1I endonuclease as a tool to investigate genomic 5–hydroxymethylcytosine
Histone acetylation controls the inactive X chromosome replication dynamics
Transcription modulation chromosome-wide: universal features and principles of dosage compensation in worms and flies
H4K20 monomethylation faces the WNT
Cortical Constriction During Abscission Involves Helices of ESCRT-III–Dependent Filaments
Interferon Antagonist NSs of La Crosse Virus Triggers a DNA Damage Response-like Degradation of Transcribing RNA Polymerase II
Different Binding Properties and Function of CXXC Zinc Finger Domains in Dnmt1 and Tet1
Usp7 and Uhrf1 control ubiquitination and stability of the maintenance DNA methyltransferase Dnmt1
Crystal structure of the sensory domain of Escherichia coli CadC, a member of the ToxR-like protein family
Nuclei of chicken neurons in tissues and three-dimensional cell cultures are organized into distinct radial zones
CpG Blocks Immunosuppression by Myeloid-Derived Suppressor Cells in Tumor-Bearing Mice
New Insights into the Signaling Mechanism of the pH-responsive, Membrane-integrated Transcriptional Activator CadC of Escherichia coli
2010
The histone methyltransferase Dot1 is required for DNA damage repair and proper development in Dictyostelium
Delivery of Immunostimulatory RNA Oligonucleotides by Gelatin Nanoparticles Triggers an Efficient Antitumoral Response
Every methyl counts – Epigenetic calculus
Fast signals and slow marks: the dynamics of histone modifications
CIPSM sponsors Kirsten Jung's project at the International Genetically Engineered Machine competition (iGEM)
Nucleosome dynamics and epigenetic stability
Developmental role for ACF1-containing nucleosome remodellers in chromatin organisation
Identification and characterization of two novel primate-specific histone H3 variants, H3.X and H3.Y
Chemical-genomic dissection of the CTD code
Dosage compensation and the global re-balancing of aneuploid genomes
Efficient Eradication of Subcutaneous but Not of Autochthonous Gastric Tumors by Adoptive T Cell Transfer in an SV40 T Antigen Mouse Model
Sensitive enzymatic quantification of 5-hydroxymethylcytosine in genomic DNA
Form and function of dosage-compensated chromosomes – a chicken-and-egg relationship
A guide to super-resolution fluorescence microscopy
Soft skills turned into hard facts: nucleosome remodelling at developmental switches
The Activation Potential of MOF Is Constrained for Dosage Compensation
Remodeling of nuclear architecture by the thiodioxoxpiperazine metabolite chaetocin
Epigenetic regulation of development by histone lysine methylation
CIPSM Excursion to Bayer Schering Pharma with Kirsten Jung
The tumor suppressor p53 connects ribosome biogenesis to cell cycle control: a double-edged sword
Novel antibody derivatives for proteome and high-content analysis
Phosphorylation of SU(VAR)3–9 by the Chromosomal Kinase JIL-1
Heterochromatin dysregulation in human diseases
Top-Down de Novo Protein Sequencing of a 13.6 kDa Camelid Single Heavy Chain Antibody by Matrix-Associated Laser Desorption Ionization-Time-of-Flight/Time-of-Flight Mass Spectrometry
Phosphorylation of histone H3T6 by PKCbI controls demethylation at histone H3K4
Replication Stress Interferes with Histone Recycling and Predeposition Marking of New Histones
Chemotherapeutic drugs inhibit ribosome biogenesis at various levels
The complexityofthe‘simple’two-component systemKdpD/KdpE in Escherichia coli
Activation of Melanoma Differentiation-Associated Gene 5 Causes Rapid Involution of the Thymus
Immunostimulatory RNA Blocks Suppression by Regulatory T Cells
The DNA binding CXC domain of MSL2 is required for faithful targeting the Dosage Compensation Complex to the X chromosome
Defects in 18S or 28S rRNA processing activate the p53 pathway
RNA Polymerase II C-terminal Heptarepeat Domain Ser-7 Phosphorylation Is Established in a Mediator-dependent Fashion
2009
The multi-domain protein Np95 connects DNA methylation and histone modification
Modulation of protein properties in living cells using nanobodies
Interaction of HP1 and Brg1/Brm with the Globular Domain of Histone H3 Is Required for HP1-Mediated Repression
Superior Protective Immunity against Murine Listeriosis by Combined Vaccination with CpG DNA and Recombinant Salmonella enterica Serovar Typhimurium
Immunostimulatory RNA Oligonucleotides Induce an Effective Antitumoral NK Cell Response through the TLR71
Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1beta production
A New Mechanism of Phosphoregulation in Signal Transduction Pathways
RNAPII CTD SER-7 phosphorylation is established in a mediator-dependent fashion
Measurement of replication structures at the nanometer scale using super-resolution light microscopy
CIPSM researcher Prof. Dr. Thomas Cremer is honored by the German Academy of Sciences Leopoldina with the Schleiden Medal
Np95 interacts with de novo DNA methyltransferases, Dnmt3a and Dnmt3b, and mediates epigenetic silencing of the viral CMV promoter in embryonic stem cells
Bundesministerium supports CIPSM cooperation of CIPSM Investigators Leonhardt and Schotta
Revealing the high-resolution three-dimensional network of chromatin and interchromatin space: A novel electron-microscopic approach to reconstructing nuclear architecture
CIPSM football team rules the cup!
The regulatory interplay between membrane-integrated sensors and transport proteins in bacteria
The dosage compensation complex shapes the conformation of the X chromosome in Drosophila
A Technical Note on Quantum Dots for Multi-Color Fluorescence in situ Hybridization
Induction Kinetics of a Conditional pH Stress Response System in Escherichia coli
Proteome-wide prediction of acetylation substrates
Proapoptotic signaling induced by RIG-I and MDA-5 results in type I interferon–independent apoptosis in human melanoma cells
Heterogeneity in quorum sensing-regulated bioluminescence of Vibrio harveyi
Changes of higher order chromatin arrangements during major genome activation in bovine preimplantation embryos
Domain swapping reveals that the N-terminal domain of the sensor kinase KdpD in Escherichia coli is important for signaling
CDK9 directs H2B monoubiquitination and controls replication-dependent histone mRNA 3'-end processing
5'-triphosphate RNA requires base-paired structures to activate antiviral signaling via RIG-I
DNA Methylation-Mediated Epigenetic Control
Chromosome shattering: a mitotic catastrophe due to chromosome condensation failure
Establishment of Histone Modifications after Chromatin Assembly
MBD4 and MLH1 are required for apoptotic induction in xDNMT1-depleted embryos
The HP1a–CAF1–SetDB1-containing complex provides H3K9me1 for Suv39-mediated K9me3 in pericentric heterochromatin
TFIIH Kinase Places Bivalent Marks on the Carboxy-Terminal Domain of RNA Polymerase II
Stimulation of the potassium sensor KdpD kinase activity by interaction with the phosphotransferase protein IIANtr in Escherichia coli
Drosophila ISWI Regulates the Association of Histone H1 With Interphase Chromosomes in Vivo
Nuclear Architecture of Rod Photoreceptor Cells Adapts to Vision in Mammalian Evolution
Drosophila HP1c Is Regulated by an Auto-Regulatory Feedback Loop through Its Binding Partner Woc
Synergy between CD26/DPP-IV Inhibition and G-CSF Improves Cardiac Function after Acute Myocardial Infarction
Active promoters and insulators are marked by the centrosomal protein 190
How are signals transduced across the cytoplasmic membrane? Transport proteins as transmitter of information
Spatiotemporal Dynamics of Regulatory Protein Recruitment at DNA Damage Sites
Dimerization of DNA Methyltransferase 1 Is Mediated by Its Regulatory Domain
Backbone Structure of Transmembrane Domain IX of the Naþ/Proline Transporter PutP of Escherichia coli
A versatile non-radioactive assay for DNA methyltransferase activity and DNA binding
Monomethylation of Lysine 20 on Histone H4 Facilitates Chromatin Maturation
2008
The Chromosomal High-Affinity Binding Sites for the Drosophila Dosage Compensation Complex
The Universal Stress Protein UspC Scaffolds the KdpD/KdpE Signaling Cascade of Escherichia coli under Salt Stress
Recruitment of RNA polymerase II cofactor PC4
5´-triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma
Short-term activation induces multifunctional dendritic cells that generate potent antitumor T-cell responses in vivo
Discontinuous movement of mRNP particles in nucleoplasmic regions devoid of chromatin
Identifying specific protein interaction partners using quantitative mass spectrometry and bead proteomes
Camelid immunoglobulins and nanobody technology
Combined Use of RNAi and Quantitative Proteomics to Study Gene Function in Drosophila
PR-SET7 and SUV4-20H regulate H4 lysine-20 methylation at imprinting control regions in the mouse
Function of Transmembrane Domain IX in the Na+/Proline Transporter PutP
A fluorescent two-hybrid (F2H) assay for direct visualization of protein interactions in living cells
Uncoupling the replication machinery
Targeting CpG Oligonucleotides to the Lymph Node by Nanoparticles Elicits Efficient Antitumoral Immunity
Nuclear transit of the RNA-binding protein She2 is required for translational control of localized ASH1 mRNA
Subdiffraction Multicolor Imaging of the Nuclear Periphery with 3D Structured Illumination Microscopy
A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse
The PHD Domain of Np95 (mUHRF1) Is Involved in Large-Scale Reorganization of Pericentromeric Heterochromatin
Photorhabdus luminescens genes induced upon insect infection
Simultaneous Transport of Different Localized mRNA Species Revealed by Live-Cell Imaging
Molecular evolution of the RNA polymerase II CTD
Generation and Characterization of a Rat Monoclonal Antibody Specific for Multiple Red Fluorescent Proteins
Simple generation of site-directed point mutations in the Escherichia coli chromosome using Red®/ET® Recombination
DNA vaccination efficiently induces antibodies to Nogo-A and does not exacerbate experimental autoimmune encephalomyelitis
ATP-dependent chromatosome remodeling
CIPSM-Researcher Heinrich Leonhardt wins Binder-Innovation Award 2008
DNA sequence and the organization of chromosomal domains
The nucleolar SUMO-specific protease SENP3 reverses SUMO modification of nucleophosmin and is required for rRNA processing
Fine Mapping of Posttranslational Modifications of the Linker Histone H1 from Drosophila melanogaster
Chromatin proteomics and epigenetic regulatory circuits
2007
Structure-function analysis of the RNA helicase maleless
Seven Ups the Code
Transcribing RNA Polymerase II Is Phosphorylated at CTD Residue Serine-7
Serine-7 of the RNA Polymerase II CTD Is Specifically Required for snRNA Gene Expression
Structure–function analysis of the RNA polymerase cleft loops elucidates initial transcription, DNA unwinding and RNA displacement
Probing Intranuclear Environments at the Single-Molecule Level
NC2 mobilizes TBP on core promoter TATA boxes
A mutagenesis strategy combining systematic alanine scanning with larger mutations to study protein interactions
Feedback-regulated poly(ADP-ribosyl)ation by PARP-1 is required for rapid response to DNA damage in living cells
A Versatile Nanotrap for Biochemical and Functional Studies with Fluorescent Fusion Proteins
Maintenance of imprinting and nuclear architecture in cycling cells
Right Margin