Tuning Photochromic Ion Channel Blockers

ACS Chem. Neuroscience, 2011, DOI: 10.1021/cn200037p, 2 (9), pp 536–543 published on 09.06.2011

ACS Chem. Neuroscience, online article

Photochromic channel blockers provide a conceptually simple and convenient way to modulate neuronal activity with light. We have recently described a family of azobenzenes that function as tonic blockers of Kv channels but require UV-A light to unblock and need to be actively switched by toggling between two different wavelengths. We now introduce red-shifted compounds that fully operate in the visible region of the spectrum and quickly turn themselves off in the dark. Furthermore, we have developed a version that does not block effectively in the dark-adapted state, can be switched to a blocking state with blue light, and reverts to the inactive state automatically. Photochromic blockers of this type could be useful for the photopharmacological control of neuronal activity under mild conditions.



TU München
Helmholz Muenchen
MPI of Neurobiology
MPI of Biochemistry