Research Area E



  Season's Greetings and Best Wishes for a Happy New Year from CIPSM
  Cell-Penetrating and Neurotargeting Dendritic siRNA Nanostructures
  Effective GTP-Replacing FtsZ Inhibitors and Antibacterial Mechanism of Action
  Deciphering the role of the type II glyoxalase isoenzyme YcbL (GlxII-2) in Escherichia coli
  Structure of a Putative Fluorinated Natural Product from Streptomyces sp. TC1
  CIPSM-Business: CIPSM closes licence deal with BASF
  Making Fast Photoswitches Faster—Using Hammett Analysis to Understand the Limit of Donor–Acceptor Approaches for Faster Hemithioindigo Photoswitches
  Watson–Crick Base Pairing Controls Excited-State Decay in Natural DNA
  PAS-cal: A repetitive peptide sequence calibration standard for MALDI mass spectrometry
  Selective Inhibition of the Immunoproteasome by Ligand-Induced Crosslinking of the Active Site
  Rescuing DNA repair activity by rewiring the H-atom transfer pathway in the radical SAM enzyme, spore photoproduct lyase
  Target discovery of acivicin in cancer cells elucidates its mechanism of growth inhibition
  Enhanced in Vivo Efficacy of a Type I Interferon Superagonist with Extended Plasma Half-life in a Mouse Model of Multiple Sclerosis
  High susceptibility to fatty liver disease in two-pore channel 2-deficient mice
  Ion mobility tandem mass spectrometry enhances performance of bottom-up proteomics
  Ribose-Protonated DNA Base Excision Repair: A Combined Theoretical and Experimental Study
  Making the Bend: DNA Tertiary Structure and Protein-DNA Interactions
  Exzellenzcluster trifft 8. Klasse am Gymnasium
  The Biocatalytic Repertoire of Natural Biaryl Formation
  Characterization of acute myeloid leukemia based on levels of global hydroxymethylation
  A Fab fragment directed against the neural cell adhesion molecule L1 enhances functional recovery after injury of the adult mouse spinal cord
  A multivariate approach to the integration of multi-omics datasets
  Mass-spectrometry-based draft of the human proteome
  PAS-cal: a Generic Recombinant Peptide Calibration Standard for Mass Spectrometry
  Tet oxidizes thymine to 5-hydroxymethyluracil in mouse embryonic stem cell DNA
  Derivatization of Antibody Fab Fragments: A Designer Enzyme for Native Protein Modification
  Structural Basis for the Site-Specific Incorporation of Lysine Derivatives into Proteins
  New Affinity Probe Targeting VEGF Receptors for Kinase Inhibitor Selectivity Profiling by Chemical Proteomics
  Probing SH2-domains using Inhibitor Affinity Purification (IAP)
  Charge separation and charge delocalization identified in long-living states of photoexcited DNA
  A Subfamily of Bacterial Ribokinases Utilizes a Hemithioacetal for Pyridoxal Phosphate Salvage
  Fingerprinting DNA Oxidation Processes: IR Characterization of the 5-Methyl-2′-Deoxycytidine Radical Cation
  A β-Lactone-Based Antivirulence Drug Ameliorates Staphylococcus aureus Skin Infections in Mice
  CIPSM Awards 2014
  Targeted Mutagenesis Results in an Activation of DNA Methyltransferase 1 and Confirms an Autoinhibitory Role of its RFTS Domain
  Biochemical Analysis of Recombinant AlkJ from Pseudomonas putida Reveals a Membrane-Associated, Flavin Adenine Dinucleotide- Dependent Dehydrogenase Suitable for the Biosynthetic Production of Aliphatic Aldehydes
  Structure-guided engineering of Anticalins with improved binding behavior and biochemical characteristics for application in radio-immuno imaging and/or therapy
  Formation and Direct Repair of UV-induced Dimeric DNA Pyrimidine Lesions
  Synthesis of functionalized α-trifluoroethyl amine scaffolds via Grignard addition to N-aryl hemiaminal ethers
  Anticalins: Exploiting a non-Ig scaffold with hypervariable loops for the engineering of binding proteins
  A new chemical probe for quantitative proteomic profiling of fibroblast growth factor receptor and its inhibitors
  Omuralide and Vibralactone: Differences in the Proteasome- β-Lactone-γ-Lactam Binding Scaffold Alter Target Preferences
  Synthese eines DNA-Promotorsegments mit allen vier epigenetischen Nukleosiden: 5-Methyl-, 5-Hydroxymethyl-, 5-Formyl- und 5-Carboxy-2′-Desoxycytidin


  Frohe Weinhachten und ein gutes neues Jahr!
  Sortase-catalyzed in vitro functionalization of a HER2-specific recombinant Fab for tumor targeting of the plant cytotoxin gelonin
  A Photoswitchable Neurotransmitter Analogue Bound to Its Receptor
  α-Methylene-γ-butyrolactones attenuate Staphylococcus aureus virulence by inhibition of transcriptional regulation
  Structural Insights into Incorporation of Norbornene Amino Acids for Click Modification of Proteins
  β-Sultams exhibit discrete binding preferences for diverse bacterial enzymes with nucleophilic residues
  Copper-Assisted Click Reactions for Activity-Based Proteomics: Fine-Tuned Ligands and Refined Conditions Extend the Scope of Application
  Disruption of Oligomerization and Dehydroalanine Formation as Mechanisms for ClpP Protease Inhibition
  Comprehensive Identification of Proteins from MALDI Imaging
  Norbornenes in Inverse Electron-Demand Diels–Alder Reactions
  CIPSM Scientific Oktoberfest 2013
  CIPSM on the run
  Amythiamicin D and Related Thiopeptides as Inhibitors of the Bacterial Elongation Factor EF-Tu: Modification of the Amino Acid at Carbon Atom C2 of Ring C Dramatically Influences Activity
  Deamination, Oxidation, and C−C Bond Cleavage Reactivity of 5‑Hydroxymethylcytosine, 5‑Formylcytosine, and 5‑Carboxycytosine
  DMSO enhances electrospray response, boosting sensitivity of proteomic experiments
  A New Class of Rhomboid Protease Inhibitors Discovered by Activity-Based Fluorescence Polarization
  Global Proteome Analysis of the NCI-60 Cell Line Panel
  Characterization of a high field Orbitrap mass spectrometer for proteome analysis
  Structural and functional insights into caseinolytic proteases reveal an unprecedented regulation principle of their catalytic triad
  The Two Faces of Potent Antitumor Duocarmycin-Based Drugs: A Structural Dissection Reveals Disparate Motifs for DNA versus Aldehyde Dehydrogenase 1 Affinity
  The Two Faces of Potent Antitumor Duocarmycin-Based Drugs: A Structural Dissection Reveals Disparate Motifs for DNA versus Aldehyde Dehydrogenase 1 Affinity
  Crystallographic Analysis and Structure-Guided Engineering of NADPH-Dependent Ralstonia sp. Alcohol Dehydrogenase Toward NADH Cosubstrate Specificity
  Nature calls CIPSM a prime example for a working conduit between university, non-university and R&D business in Germany. „CIPSM features regularly in the Nature Publicing Index“
  Characterization of a Chemical Affinity Probe Targeting Akt Kinases
  Measuring and Managing Ratio Compression for Accurate iTRAQ/ TMT Quantification
  PASylation: a biological alternative to PEGylation for extending the plasma half-life of pharmaceutically active proteins
  Total Synthesis of the Hypermodified tRNA Nucleoside Epoxyqueuosine
  A large synthetic peptide and phosphopeptide reference library for mass spectrometry–based proteomics
  Unexpected non-Hoogsteen–based mutagenicity mechanism of FaPy-DNA lesions
  MScDB: A Mass Spectrometry-centric Protein Sequence Database for Proteomics
  Cleavable trifunctional biotin reagents for protein labelling, capture and release
  Proteomic workflow for analysis of archival formalin-fixed and paraffin-embedded clinical samples to a depth of 10 000 proteins
  Structural basis for the enzymatic formation of the key strawberry flavor compound 4-hydroxy-2,5-dimethyl-3(2H)-furanone
  Comparing Immobilized Kinase Inhibitors and Covalent ATP Probes for Proteomic Profiling of Kinase Expression and Drug Selectivity
  The Mechanism of Caseinolytic Protease (ClpP) Inhibition
  Combinatorial Design of an Anticalin Directed against the Extra-Domain B for the Specific Targeting of Oncofetal Fibronectin
  Dynamic Readers for 5-(Hydroxy)Methylcytosine and Its Oxidized Derivatives
  Total Synthesis of the Hypermodified RNA Bases Wybutosine and Hydroxywybutosine and Their Quantification Together with Other Modified RNA Bases in Plant Materials
  Tuning probe selectivity for chemical proteomics applications
  Conformational Selection in Substrate Recognition by Hsp70 Chaperones
  Activity-based probes for rhomboid proteases discovered in a mass spectrometry-based assay
  Crystal structure of the ω-aminotransferase from Paracoccus denitrificans and its phylogenetic relationship with other class III amino- transferases that have biotechnological potential
  Proteome Wide Purification and Identification of O-GlcNAc-Modified Proteins Using Click Chemistry and Mass Spectrometry
  Synthesis of 5-Hydroxymethyl-, 5-Formyl-, and 5-Carboxycytidine-triphosphates and Their Incorporation into Oligonucleotides by Polymerase Chain Reaction
  Synthesis of ε-N-propionyl-, ε-N-butyryl-, and ε-N-crotonyl-lysine containing histone H3 using the pyrrolysine system
  Total Syntheses and Biological Evaluation of 3-O-Methylfunicone and Its Derivatives Prepared by TMPZnCl·LiCl-Mediated Halogenation and Carbonylative Stille Cross-Coupling


  SCFFbxo9 and CK2 direct the cellular response to growth factor withdrawal via Tel2/Tti1 degradation and promote survival in multiple myeloma
  Target profiling of 4-hydroxyderricin in S. aureus reveals seryl-tRNA synthetase binding and inhibition by covalent modification
  Alternative bacterial two-component small heat shock protein systems
  The radical SAM enzyme spore photoproduct lyase employs a tyrosyl radical for DNA repair
  Structure, phosphorylation and U2AF65 binding of the N-terminal domain of splicing factor 1 during 30-splice site recognition
  Synthesis of ε-N-propionyl-, ε-N-butyryl-, and ε-N-crotonyl-lysine containing histone H3 using the pyrrolysine system
  Quantification of the N-glycosylated Secretome by Super-SILAC During Breast Cancer Progression and in Human Blood Samples*
  Isotope-Based Analysis of Modified tRNA Nucleosides Correlates Modification Density with Translational Efficiency
  A Simple and Effective Cleavable Linker for Chemical Proteomics Applications Yinliang Yang,
  Label-Free Microscale Thermophoresis Discriminates Sites and Affinity of Protein–Ligand Binding
  Deactivation of the E. coli pH Stress Sensor CadC by Cadaverine
  Global analysis of genome, transcriptome and proteome reveals the response to aneuploidy in human cells
  Azo-Propofols: Photochromic Potentiators of GABAA Receptors
  Evolution of a Synthetic Strategy for the Variecolortide
  A Conformationally Frozen Peptoid Boosts CXCR4 Affinity and Anti-HIV Activity
  Nature mentions CIPSMs’ graduate educational program in it’s highlight article about the German Excellence Initiative
  Homotypic Interaction and Amino Acid Distribution of Unilaterally Conserved Transmembrane Helices
  Exploring the Pharmacology and Action Spectra of Photochromic Open-Channel Blockers
  In vitro Percutaneous Absorption of 14C-Labeled β-Lactone Promises Topical Delivery of New Bacterial Virulence Inhibitors
  Structural insights into recognition and repair of UV-DNA damage by Spore Photoproduct Lyase, a radical SAM enzyme
  Structure and Function of Noncanonical Nucleobases
  CIPSM selected as Cluster of Excellence once more... YEAH!
  Dynamics of ultraviolet-induced DNA lesions: Dewar formation guided by pre-tension induced by the backbone
  Sequence-dependent backbone dynamics of a viral fusogen transmembrane helix
  Discovery of the HSP90 regulated proteome by CIPSM scientists featured on the cover of Mol Cell Proteomics
  Synthetic approaches toward sesterterpenoids
  A Unified Approach to trans-Hydrindane Sesterterpenoids
  Mechanism and Stem-Cell Activity of 5-Carboxycytosine Decarboxylation Determined by Isotope Tracing
  Stereoselective Total Syntheses of Herbicidin C and Aureonuclemycin through Late-Stage Glycosylation
  ONIOM approach for non-adiabatic on-the-fly molecular dynamics demonstrated for the backbone controlled Dewar valence isomerization
  Pretubulysin derived probes as novel tools for monitoring the microtubule network via activity-based protein profiling and fluorescence microscopy
  A Total Synthesis Prompts the Structure Revision of Haouamine B
  A Genetically Encoded Norbornene Amino Acid for the Mild and Selective Modification of Proteins in a Copper-Free Click Reaction
  A Photochromic Agonist of AMPA Receptors
  Electrophilic natural products and their biological targets
  Mechanism of Translesion Transcription by RNA Polymerase II and Its Role in Cellular Resistance to DNA Damage
  H2A.Z.2.2 is an alternatively spliced histone H2A.Z variant that causes severe nucleosome destabilization
  The CDK5 repressor CDK5RAP1 is a methylthiotransferase acting on nuclear and mitochondrial RNA
  Total Synthesis of Exiguamines A and B Inspired by Catecholamine Chemistry
  The 19S Cap Puzzle: A New Jigsaw Piece
  Radiolabelled RGD peptides for imaging and therapy
  Rapid optical control of nociception with an ion-channel photoswitch
  Rapid optical control of nociception with an ion-channel photoswitch
  Immuno- and Constitutive Proteasome Crystal Structures Reveal Differences in Substrate and Inhibitor Specificity
  Discovery and Mutagenicity of a Guanidinoformimine Lesion as a new Intermediate of the Oxidative Deoxyguanosine Degradation Pathway
  Consecutive Proteolytic Digestion in an Enzyme Reactor Increases Depth of Proteomic and Phosphoproteomic Analysis
  Crystal Structure of Methylornithine Synthase (PylB): Insights into the Pyrrolysine Biosynthesis
  Exploiting nature’s rich source of proteasome inhibitors as starting points in drug development
  Crystal Structures of Mutant IspH Proteins Reveal a Rotation of the Substrate's Hydroxymethyl Group during Catalysis
  An Approach to Aminonaphthoquinone Ansamycins Using a Modified Danishefsky Diene
  Insights into the Structural Network Responsible for Oligomerization and Activity of the Bacterial Virulence Regulator Caseinolytic Protease P (Clpp)
  Development and characterization of improved β-lactone-based anti-virulence drugs targeting Clp
  Optochemical control of genetically engineered neuronal nicotinic acetylcholine receptors
  Low values of 5-hydroxymethylcytosine (5hmC), the ‘‘sixth base,’’ are associated with anaplasia in human brain tumors
  Mechanism of UV-Induced Formation of Dewar Lesions in DNA
  The architecture of functional modules in the Hsp90 co-chaperone Sti1/Hop
  Beta-Lactams and Beta-lactones as activity-based probes in chemical biology
  Tetraalkylcuprates(III): Formation, Association, and Intrinsic Reactivity


  Optochemical Genetics
  Improved Synthesis and Mutagenicity of Oligonucleotides Containing 5-Hydroxymethylcytosine, 5-Formylcytosine and 5-Carboxylcytosine
  Vibralactone as a Tool to Study the Activity and Structure of the ClpP1P2 Complex from Listeria monocytogenes
  Deep proteome and transcriptome mapping of a human cancer cell line
  The RIG-I ATPase domain structure reveals insights into ATP-dependent antiviral signalling
  Systems-Based Analysis of Modified tRNA Bases
  Pictures of the Scientific Oktoberfest 2011
  Scientific Oktoberfest: CIPSM-Fest of Chemical Biology 2011
  Design, Synthesis, and Functionalization of Dimeric Peptides Targeting Chemokine Receptor CXCR4
  Reversible bond formation enables the replication and amplification of a crosslinking salen complex as an orthogonal base pair
  The Discovery of 5-Formylcytosine in Embryonic Stem Cell DNA
  PET Imaging of CXCR4 Receptors in Cancer by a New Optimized Ligand
  5-Hydroxymethylcytosine, the Sixth Base of the Genome
  Unraveling the Protein Targets of Vancomycin in Living S. aureus and E. faecalis Cells
  Evaluation of α-Pyrones and Pyrimidones as Photoaffinity Probes for Affinity-Based Protein Profiling
  Recognition of 5-Hydroxymethylcytosine by the Uhrf1 SRA Domain
  An efficient synthesis of loline alkaloids
  Tuning Photochromic Ion Channel Blockers
  Identification and characterization of a novel ubiquitous nucleolar protein ‘NARR’ encoded by a gene overlapping the rab34 oncogene
  A Conformational Switch Underlies ClpP Protease Function
  High Recovery FASP Applied to the Proteomic Analysis of Microdissected Formalin Fixed Paraffin Embedded Cancer Tissues Retrieves Known Colon Cancer Markers
  A Novel Two-Stage Tandem Mass Spectrometry Approach and Scoring Scheme for the Identification of O-GlcNAc Modified Peptides
  Discovery and Synthesis of New UV-Induced Intrastrand C(4−8)G and G(8−4)C Photolesions
  Alkyne derivatives of isocoumarins as clickable activity-based probes for serine proteases
  Structure and dynamics of the lipid modifications of a transmembrane Alpha-helical peptide determined by 2H solid-state NMR spectroscopy
  Biosynthesis of a Fluorescent Protein with Extreme Pseudo-Stokes Shift by Introducing a Genetically Encoded Non-Natural Amino Acid outside the Fluorophore
  Synthetic Studies toward A-74528
  The ribosomaltunnelasafunctionalenvironmentfornascent polypeptide foldingandtranslationalstalling
  Concise Total Syntheses of Variecolortides A and B through an Unusual Hetero-Diels–Alder Reaction
  Crystal structure of the sensory domain of Escherichia coli CadC, a member of the ToxR-like protein family
  Elucidation of the a-Keto-Aldehyde Binding Mechanism: A Lead Structure Motif for Proteasome Inhibition
  New Insights into the Signaling Mechanism of the pH-responsive, Membrane-integrated Transcriptional Activator CadC of Escherichia coli
  The natural product hybrid of Syringolin A and Glidobactin A synergizes proteasome inhibition potency with subsite selectivity


  Protein Reactivity of Natural Product-Derived γ-Butyrolactones
  Tissue Distribution of 5-Hydroxymethylcytosine and Search for Active Demethylation Intermediates
  Biosynthesis of Isoprenoids: Crystal Structure of the [4Fe–4S] Cluster Protein IspG
  Elucidation of the a-Keto-Aldehyde Binding Mechanism: A Lead Structure Motif for Proteasome Inhibition
  Comparison of ultrafiltration units for proteomic and N-glycoproteomic analysis by the filter-aided sample preparation method
  Toward the Total Synthesis of Maoecrystal V: Establishment of Contiguous Quaternary Stereocenters
  Mechanism of replication blocking and bypass of Y-family polymerase Eta by bulky acetylaminofluorene DNA adducts
  Ferredoxin:NADPH oxidoreductase is recruited to thylakoids by binding to a polyproline type II helix in a pH-dependent manner
  Confident phosphorylation site localization using the Mascot Delta Score
  Confident phosphorylation site localization using the Mascot Delta Score
  Residue-Specific Side-Chain Packing Determines the Backbone Dynamics of Transmembrane Model Helices
  The biological targets of acivicin inspired 3-chloro- and 3-bromodihydroisoxazole scaffolds
  Reductive Dehydroxylation of Allyl Alcohols by IspH Protein
  Pharmacology of ionotropic glutamate receptors: A structural perspective
  CIPSM spin-off AVIRU gets funding from the German Parliament
  Synthesis and Antiplasmodial Activity of Highly Active Reverse Analogues of the Antimalarial Drug Candidate Fosmidomycin
  20S Proteasome Inhibition: Designing Noncovalent Linear Peptide Mimics of the Natural Product TMC-95A
  Total synthesis of newbouldine via reductive N - N bond formation
  Quantification of the Sixth DNA Base Hydroxymethylcytosine in the Brain
  Biomimetic Synthesis of (−)-Pycnanthuquinone C through the Diels–Alder Reaction of a Vinyl Quinone
  Convergent Synthesis and Biological Evaluation of Syringolin A and Derivatives as Eukaryotic 20S Proteasome Inhibitors
  Proteomics: a pragmatic perspective
  CIPSM spin-off XL-protein GmbH awarded with the 2010 Science4Life Venture Cup
  Chemical Probes for Labeling of the Bacterial Glucosaminidase NagZ via the Huisgen Cycloaddition
  The 26S proteasome: assembly and function of a destructive machine
  CIPSM at the elementary school
  Proteome, Phosphoproteome, and N-Glycoproteome Are Quantitatively Preserved in Formalin-Fixed Paraffin-Embedded Tissue and Analyzable by High-Resolution Mass Spectrometry
  Exzellenzinitiative für die Grundschule - CIPSM unterrichtet Grundschüler
  Thomas Carell was honored with the Cross of Merit on ribbon of the Federal Republic of Germany
  Showdomycin as a Versatile Chemical Tool for the Detection of Pathogenesis-Associated Enzymes in Bacteria
  Brain Phosphoproteome Obtained by a FASP-Based Method Reveals Plasma Membrane Protein Topology
  Oxidation State, Aggregation, and Heterolytic Dissociation of Allyl Indium Reagents
  Crystal Structure of a Cisplatin-(1,3-GTG) Cross-Link within DNA Polymerase eta
  Natural Products and Their Biological Targets: Proteomic and Metabolomic Labeling Strategies
  DNA (6-4) Photolyases Reduce Dewar Isomers for Isomerization into (6-4) Lesions
  A Highly Charged Ag6 4+ Core in a DNA-Encapsulated Silver Nanocluster
  Probing the reaction mechanism of IspH protein by x-ray structure analysis
  Structural features of fusogenic model transmembrane domains that differentially regulate inner and outer leaflet mixing in membrane fusion


  Ionic interactions promote transmembrane helix-helix association depending on sequence context
  Phosducin influences sympathetic activity and prevents stress-induced hypertension in humans and mice
  Synthesis of Threefold Glycosylated Proteins using Click Chemistry and Genetically Encoded Unnatural Amino Acids
  Light Commands Ion Channel
  Microsolvated and Chelated Butylzinc Cations: Formation, Relative Stability, and Unimolecular Gas-Phase Chemistry
  Combination of FASP and StageTip-Based Fractionation Allows In-Depth Analysis of the Hippocampal Membrane Proteome
  CIPSM PI and board member Arne Skerra and his new spin-off company XL-protein GmbH prolong the plasma half-life of biopharmaceutical substances
  DynaDock: A new molecular dynamics-based algorithm for protein-peptide docking including receptor flexibility
  A Photolabile Linker for the Mild and Selective Cleavage of Enriched Biomolecules from Solid Support
  A new crystal form of human tear lipocalin reveals high flexibility in the loop region and induced fit in the ligand cavity
  Parallel Isotope-Based Quantification of Modified tRNA Nucleosides
  Syringolin A Selectively Labels the 20S Proteasome in Murine EL4 and Wild-Type and Bortezomib-Adapted Leukaemic Cell Lines
  Once Overlooked, Now Made Visible: ATL Proteins and DNA Repair
  Crystal Structure of the T(6-4)C Lesion in Complex with a (6-4) DNA Photolyase and Repair of UV-Induced (6-4) and Dewar Photolesions
  Snapshots of the Fluorosalinosporamide/20S Complex Offer Mechanistic Insights for Fine Tuning Proteasome Inhibition
  beta-Lactones Decrease the Intracellular Virulence of Listeria monocytogenes in
  Prolonged stability by cyclization: Macrocyclic phosphino dipeptide isostere inhibitors of ß-secretase (BACE1)
  A new ground state single electron donor for excess electron transfer studies in DNA
  Structure of Active IspH Enzyme from Escherichia coli Provides Mechanistic Insights into Substrate Reduction
  NMR Structure and Dynamics of the Engineered Fluorescein-Binding Lipocalin FluA Reveal Rigidification of β-Barrel and Variable Loops upon Enthalpy-Driven Ligand Binding
  Alpenforum 2009
  Structural biology of DNA photolyases and cryptochromes
  CIPSM-Harvard Young Scientists' Forum (YSF)
  Cinnamic aldehyde derived probes for the active site labelling of pathogenesis associated enzymes
  Interaction and conformational dynamics of membrane-spanning protein helices
  Stabilization of conformationally dynamic helices by covalently attached acyl chains
  Bilder von der CIPSM-Festveranstaltung im Deutschen Museum am 4. Mai 2009
  An engineered lipocalin specific for CTLA-4 reveals a combining site with structural and conformational features similar to antibodies
  CIPSM-Festveranstaltung im Deutschen Museum am 4. Mai 2009
  The archaeal cofactor F0 is a light-harvesting antenna chromophore in eukaryotes
  Design of anti- and pro-aggregation variants to assess the effects of methionine oxidation in human prion protein
  Natural product inhibitors of protein–protein interactions mediated by Src-family SH2 domains
  Synthetic and structural studies on syringolin A and B reveal critical determinants of selectivity and potency of proteasome inhibition
  Universal sample preparation method for proteome analysis
  Sequence-specific conformational dynamics of model transmembrane domains determines their membrane fusogenic function
  beta-Lactam Probes As Selective Chemical-Proteomic Tools for the Identification and Functional Characterization of Resistance Associated Enzymes in MRSA
  Copper-Free “Click” Modification of DNA via Nitrile Oxide-Norbornene 1,3-Dipolar Cycloaddition
  Protein Iodination by Click Chemistry
  CIPSM Movie online stream
  Allosteric Switches: Remote Controls for Proteins
  Unraveling the Secrets of Protein-Metabolite Interactions
  Imaging of integrin alpha-v-beta-3 expression in patients with malignant glioma by [18F] Galacto-RGD positron emission tomography
  High-Affinity Recognition of Lanthanide(III) Chelate Complexes by a Reprogrammed Human Lipocalin 2
  Phosphorothioation of Oligonucleotides Strongly Influences the Inhibition of Bacterial (M.HhaI) and Human(Dnmt1) DNA Methyltransferases
  Structurally Refined b-Lactones as Potent Inhibitors of Devastating Bacterial Virulence Factors
  Crystal structure analysis of DNA lesion repair and tolerance mechanisms
  A Pan-Specific Inhibitor of the Polo-Box Domains of Polo-like Kinases Arrests Cancer Cells in Mitosis
  Importin 8 Is a Gene Silencing Factor that Targets Argonaute Proteins to Distinct mRNAs
  Two-polymerase mechanisms dictate error-free and error-prone translesion DNA synthesis in mammals
  Formation of Organozincate Anions in LiCl-Mediated Zinc Insertion Reactions
  Controlled Nucleation of DNA Metallization


  The persisting challenge of selective and specific proteasome inhibition
  Aggregation and Reactivity of Organozincate Anions Probed by Electrospray Mass Spectrometry
  Recognition and repair of UV lesions in loop structures of duplex DNA by DASH-type cryptochrome
  Identification of potential substrate proteins for the periplasmic Escherichia coli chaperone Skp
  CIPSM ist Ausgewählter Ort im Land der Ideen
  A Human snoRNA with MicroRNA-Like Functions
  Novel Diazirine-Containing DNA Photoaffinity Probes for the Investigation of DNA-Protein-Interactions
  Evidence for Insertional RNA Editing in Humans
  5'-triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma
  Complex patterns of histidine, hydroxylated amino acids and the GxxxG motif mediate high-affinity transmembrane domain interactions
  Crystal Structure and Mechanism of a DNA (6-4) Photolyase
  Structural determinants of MIF functions in CXCR2-mediated inflammatory and atherogenic leukocyte recruitment
  Leaving Groups Prolong the Duration of 20S Proteasome Inhibition and Enhance the Potency of Salinosporamides
  Azatryptophans endow proteins with intrinsic blue fluorescence
  Structural Analysis of Spiro b-Lactone Proteasome Inhibitors
  CIPSM-Researchers Stephan Sieber and Thomas Böttcher win the Innovation award 2008 of the BioRegions in Germany
  Beta-Lactones as Specific Inhibitors of ClpP Attenuate the Production of Extracellular Virulence Factors of Staphylococcus aureus
  Postsynthetic DNA Modification through the Copper-Catalyzed Azide–Alkyne Cycloaddition Reaction
  The 1.8-Å Crystal Structure of α1-Acid Glycoprotein (Orosomucoid) Solved by UV RIP Reveals the Broad Drug-Binding Activity of This Human Plasma Lipocalin
  Beta-Lactams as Selective Chemical Probes for the in Vivo Labeling of Bacterial Enzymes Involved in Cell Wall Biosynthesis, Antibiotic Resistance, and Virulence
  Hier geht was!
  Intracellular uptake and inhibitory activity of aromatic fluorinated amino acids in human breast cancer cells
  Convenient syntheses of homopropargylglycine
  Inhibition of transcription factors with small organic molecules
  Inhibition of transcription factors with small organic molecules
  Exploiting Cross-Amyloid Interactions To Inhibit Insulin Aggregation but not Function: Nanomolar Affinity Inhibition of Insulin Aggregation by an IAPP Mimic
  Biomimetic synthesis of the IDO inhibitors exiguamine A and B
  Sequence-Specific Conformational Flexibility of SNARE Transmembrane Helices Probed by Hydrogen/Deuterium Exchange
  Synthesis and properties of DNA containing a spore photoproduct analog
  Fpg (MutM) recognizes bulky N7-substituted-FapydG lesion using a novel and unproductive binding mode
  Synthesis of a Stabilized Version of the Imidazolone DNA Lesion
  Ubiquitin docking at the proteasome through a novel pleckstrin-homology domain interaction
  Docking of tryptophan analogs to trytophanyl-tRNA synthetase: implications for non-canonical amino acid incorporations
  A high-throughput assay based on fluorescence polarization for inhibitors of the polo-box domain of polo-like kinase
  Inhibition of Polo-like Kinase 1 by Blocking Polo-Box Domain-Dependent Protein-Protein Interactions
  Signal Transducers and Activators of Transcription as Targets for Small Organic Molecules
  Temperature and pressure dependence of protein stability: The engineered fluorescein-binding lipocalin FluA shows an elliptic phase diagram
  A plant pathogen virulence factor inhibits the eukaryotic proteasome by a novel mechanism
  beta-Lactones as Privileged Structures for the Active-Site Labeling of Versatile Bacterial Enzyme Classes
  Efficient N-Terminal Glycoconjugation of Proteins by the N-End Rule
  Synthetic Biology of Proteins: Tuning GFPs Folding and Stability with Fluoroproline
  Bayer Schering Pharma and CIPSM sign a strategic partnership
  Discovery of Chromone-Based Inhibitors of the Transcription Factor STAT5
  Synthesis of DNA Dumbbell Based Inhibitors for the Human DNA Methyltransferase Dnmt1
  A high-throughput assay for signal transducer and activator of transcription 5b based on fluorescence polarization
  Requirement for Small Side Chain Residues within the GxGD-Motif of Presenilin for gamma-Secretase Substrate Cleavage
  Dissecting the Differences between the a and b Anomers of the Oxidative DNA Lesion FaPydG
  The carbohydrate recognition domain of Langerin reveals high structural similarity with the one of DC-SIGN but an additional, calcium-independent sugar-binding site


TU München
Helmholz Muenchen
MPI of Neurobiology
MPI of Biochemistry