Research Area E

2013

  CIPSM Scientific Oktoberfest 2013
  Unexpected non-Hoogsteen–based mutagenicity mechanism of FaPy-DNA lesions
  Cleavable trifunctional biotin reagents for protein labelling, capture and release
  Structural basis for the enzymatic formation of the key strawberry flavor compound 4-hydroxy-2,5-dimethyl-3(2H)-furanone
  Dynamic Readers for 5-(Hydroxy)Methylcytosine and Its Oxidized Derivatives
  Total Synthesis of the Hypermodified RNA Bases Wybutosine and Hydroxywybutosine and Their Quantification Together with Other Modified RNA Bases in Plant Materials
  Tuning probe selectivity for chemical proteomics applications
  Activity-based probes for rhomboid proteases discovered in a mass spectrometry-based assay
  Synthesis of 5-Hydroxymethyl-, 5-Formyl-, and 5-Carboxycytidine-triphosphates and Their Incorporation into Oligonucleotides by Polymerase Chain Reaction
  Total Syntheses and Biological Evaluation of 3-O-Methylfunicone and Its Derivatives Prepared by TMPZnCl·LiCl-Mediated Halogenation and Carbonylative Stille Cross-Coupling

2012

  The radical SAM enzyme spore photoproduct lyase employs a tyrosyl radical for DNA repair
  Structure, phosphorylation and U2AF65 binding of the N-terminal domain of splicing factor 1 during 30-splice site recognition
  Synthesis of ε-N-propionyl-, ε-N-butyryl-, and ε-N-crotonyl-lysine containing histone H3 using the pyrrolysine system
  Isotope-Based Analysis of Modified tRNA Nucleosides Correlates Modification Density with Translational Efficiency
  A Simple and Effective Cleavable Linker for Chemical Proteomics Applications Yinliang Yang,
  Deactivation of the E. coli pH Stress Sensor CadC by Cadaverine
  Global analysis of genome, transcriptome and proteome reveals the response to aneuploidy in human cells
  A Conformationally Frozen Peptoid Boosts CXCR4 Affinity and Anti-HIV Activity
  Homotypic Interaction and Amino Acid Distribution of Unilaterally Conserved Transmembrane Helices
  Structural insights into recognition and repair of UV-DNA damage by Spore Photoproduct Lyase, a radical SAM enzyme
  Structure and Function of Noncanonical Nucleobases
  CIPSM selected as Cluster of Excellence once more... YEAH!
  Dynamics of ultraviolet-induced DNA lesions: Dewar formation guided by pre-tension induced by the backbone
  Sequence-dependent backbone dynamics of a viral fusogen transmembrane helix
  Discovery of the HSP90 regulated proteome by CIPSM scientists featured on the cover of Mol Cell Proteomics
  Mechanism and Stem-Cell Activity of 5-Carboxycytosine Decarboxylation Determined by Isotope Tracing
  ONIOM approach for non-adiabatic on-the-fly molecular dynamics demonstrated for the backbone controlled Dewar valence isomerization
  A Genetically Encoded Norbornene Amino Acid for the Mild and Selective Modification of Proteins in a Copper-Free Click Reaction
  Mechanism of Translesion Transcription by RNA Polymerase II and Its Role in Cellular Resistance to DNA Damage
  H2A.Z.2.2 is an alternatively spliced histone H2A.Z variant that causes severe nucleosome destabilization
  The CDK5 repressor CDK5RAP1 is a methylthiotransferase acting on nuclear and mitochondrial RNA
  The 19S Cap Puzzle: A New Jigsaw Piece
  Radiolabelled RGD peptides for imaging and therapy
  Rapid optical control of nociception with an ion-channel photoswitch
  Immuno- and Constitutive Proteasome Crystal Structures Reveal Differences in Substrate and Inhibitor Specificity
  Discovery and Mutagenicity of a Guanidinoformimine Lesion as a new Intermediate of the Oxidative Deoxyguanosine Degradation Pathway
  Consecutive Proteolytic Digestion in an Enzyme Reactor Increases Depth of Proteomic and Phosphoproteomic Analysis
  Crystal Structure of Methylornithine Synthase (PylB): Insights into the Pyrrolysine Biosynthesis
  Exploiting nature’s rich source of proteasome inhibitors as starting points in drug development
  Crystal Structures of Mutant IspH Proteins Reveal a Rotation of the Substrate's Hydroxymethyl Group during Catalysis
  An Approach to Aminonaphthoquinone Ansamycins Using a Modified Danishefsky Diene
  Insights into the Structural Network Responsible for Oligomerization and Activity of the Bacterial Virulence Regulator Caseinolytic Protease P (Clpp)
  Low values of 5-hydroxymethylcytosine (5hmC), the ‘‘sixth base,’’ are associated with anaplasia in human brain tumors
  Optochemical control of genetically engineered neuronal nicotinic acetylcholine receptors
  Mechanism of UV-Induced Formation of Dewar Lesions in DNA
  The architecture of functional modules in the Hsp90 co-chaperone Sti1/Hop
  Beta-Lactams and Beta-lactones as activity-based probes in chemical biology
  Tetraalkylcuprates(III): Formation, Association, and Intrinsic Reactivity

2011

  Optochemical Genetics
  Improved Synthesis and Mutagenicity of Oligonucleotides Containing 5-Hydroxymethylcytosine, 5-Formylcytosine and 5-Carboxylcytosine
  Vibralactone as a Tool to Study the Activity and Structure of the ClpP1P2 Complex from Listeria monocytogenes
  Deep proteome and transcriptome mapping of a human cancer cell line
  The RIG-I ATPase domain structure reveals insights into ATP-dependent antiviral signalling
  Systems-Based Analysis of Modified tRNA Bases
  Pictures of the Scientific Oktoberfest 2011
  Scientific Oktoberfest: CIPSM-Fest of Chemical Biology 2011
  Design, Synthesis, and Functionalization of Dimeric Peptides Targeting Chemokine Receptor CXCR4
  Reversible bond formation enables the replication and amplification of a crosslinking salen complex as an orthogonal base pair
  The Discovery of 5-Formylcytosine in Embryonic Stem Cell DNA
  PET Imaging of CXCR4 Receptors in Cancer by a New Optimized Ligand
  5-Hydroxymethylcytosine, the Sixth Base of the Genome
  Unraveling the Protein Targets of Vancomycin in Living S. aureus and E. faecalis Cells
  Recognition of 5-Hydroxymethylcytosine by the Uhrf1 SRA Domain
  An efficient synthesis of loline alkaloids
  Tuning Photochromic Ion Channel Blockers
  Identification and characterization of a novel ubiquitous nucleolar protein ‘NARR’ encoded by a gene overlapping the rab34 oncogene
  A Conformational Switch Underlies ClpP Protease Function
  High Recovery FASP Applied to the Proteomic Analysis of Microdissected Formalin Fixed Paraffin Embedded Cancer Tissues Retrieves Known Colon Cancer Markers
  A Novel Two-Stage Tandem Mass Spectrometry Approach and Scoring Scheme for the Identification of O-GlcNAc Modified Peptides
  Discovery and Synthesis of New UV-Induced Intrastrand C(4−8)G and G(8−4)C Photolesions
  Alkyne derivatives of isocoumarins as clickable activity-based probes for serine proteases
  Structure and dynamics of the lipid modifications of a transmembrane Alpha-helical peptide determined by 2H solid-state NMR spectroscopy
  Biosynthesis of a Fluorescent Protein with Extreme Pseudo-Stokes Shift by Introducing a Genetically Encoded Non-Natural Amino Acid outside the Fluorophore
  Synthetic Studies toward A-74528
  Concise Total Syntheses of Variecolortides A and B through an Unusual Hetero-Diels–Alder Reaction
  Crystal structure of the sensory domain of Escherichia coli CadC, a member of the ToxR-like protein family
  Elucidation of the a-Keto-Aldehyde Binding Mechanism: A Lead Structure Motif for Proteasome Inhibition
  New Insights into the Signaling Mechanism of the pH-responsive, Membrane-integrated Transcriptional Activator CadC of Escherichia coli
  The natural product hybrid of Syringolin A and Glidobactin A synergizes proteasome inhibition potency with subsite selectivity
  downloads

2010

  Tissue Distribution of 5-Hydroxymethylcytosine and Search for Active Demethylation Intermediates
  Biosynthesis of Isoprenoids: Crystal Structure of the [4Fe–4S] Cluster Protein IspG
  Elucidation of the a-Keto-Aldehyde Binding Mechanism: A Lead Structure Motif for Proteasome Inhibition
  Comparison of ultrafiltration units for proteomic and N-glycoproteomic analysis by the filter-aided sample preparation method
  Toward the Total Synthesis of Maoecrystal V: Establishment of Contiguous Quaternary Stereocenters
  Mechanism of replication blocking and bypass of Y-family polymerase Eta by bulky acetylaminofluorene DNA adducts
  Ferredoxin:NADPH oxidoreductase is recruited to thylakoids by binding to a polyproline type II helix in a pH-dependent manner
  Confident phosphorylation site localization using the Mascot Delta Score
  Residue-Specific Side-Chain Packing Determines the Backbone Dynamics of Transmembrane Model Helices
  Reductive Dehydroxylation of Allyl Alcohols by IspH Protein
  Pharmacology of ionotropic glutamate receptors: A structural perspective
  CIPSM spin-off AVIRU gets funding from the German Parliament
  Synthesis and Antiplasmodial Activity of Highly Active Reverse Analogues of the Antimalarial Drug Candidate Fosmidomycin
  20S Proteasome Inhibition: Designing Noncovalent Linear Peptide Mimics of the Natural Product TMC-95A
  Total synthesis of newbouldine via reductive N - N bond formation
  Quantification of the Sixth DNA Base Hydroxymethylcytosine in the Brain
  Biomimetic Synthesis of (−)-Pycnanthuquinone C through the Diels–Alder Reaction of a Vinyl Quinone
  Convergent Synthesis and Biological Evaluation of Syringolin A and Derivatives as Eukaryotic 20S Proteasome Inhibitors
  Proteomics: a pragmatic perspective
  CIPSM spin-off XL-protein GmbH awarded with the 2010 Science4Life Venture Cup
  The 26S proteasome: assembly and function of a destructive machine
  CIPSM at the elementary school
  Proteome, Phosphoproteome, and N-Glycoproteome Are Quantitatively Preserved in Formalin-Fixed Paraffin-Embedded Tissue and Analyzable by High-Resolution Mass Spectrometry
  Exzellenzinitiative für die Grundschule - CIPSM unterrichtet Grundschüler
  Thomas Carell was honored with the Cross of Merit on ribbon of the Federal Republic of Germany
  Showdomycin as a Versatile Chemical Tool for the Detection of Pathogenesis-Associated Enzymes in Bacteria
  Brain Phosphoproteome Obtained by a FASP-Based Method Reveals Plasma Membrane Protein Topology
  Oxidation State, Aggregation, and Heterolytic Dissociation of Allyl Indium Reagents
  Crystal Structure of a Cisplatin-(1,3-GTG) Cross-Link within DNA Polymerase eta
  Natural Products and Their Biological Targets: Proteomic and Metabolomic Labeling Strategies
  DNA (6-4) Photolyases Reduce Dewar Isomers for Isomerization into (6-4) Lesions
  A Highly Charged Ag6 4+ Core in a DNA-Encapsulated Silver Nanocluster
  Probing the reaction mechanism of IspH protein by x-ray structure analysis
  Structural features of fusogenic model transmembrane domains that differentially regulate inner and outer leaflet mixing in membrane fusion

2009

  Ionic interactions promote transmembrane helix-helix association depending on sequence context
  Phosducin influences sympathetic activity and prevents stress-induced hypertension in humans and mice
  Synthesis of Threefold Glycosylated Proteins using Click Chemistry and Genetically Encoded Unnatural Amino Acids
  Light Commands Ion Channel
  Microsolvated and Chelated Butylzinc Cations: Formation, Relative Stability, and Unimolecular Gas-Phase Chemistry
  Combination of FASP and StageTip-Based Fractionation Allows In-Depth Analysis of the Hippocampal Membrane Proteome
  CIPSM PI and board member Arne Skerra and his new spin-off company XL-protein GmbH prolong the plasma half-life of biopharmaceutical substances
  DynaDock: A new molecular dynamics-based algorithm for protein-peptide docking including receptor flexibility
  A Photolabile Linker for the Mild and Selective Cleavage of Enriched Biomolecules from Solid Support
  A new crystal form of human tear lipocalin reveals high flexibility in the loop region and induced fit in the ligand cavity
  Parallel Isotope-Based Quantification of Modified tRNA Nucleosides
  Syringolin A Selectively Labels the 20S Proteasome in Murine EL4 and Wild-Type and Bortezomib-Adapted Leukaemic Cell Lines
  Once Overlooked, Now Made Visible: ATL Proteins and DNA Repair
  Crystal Structure of the T(6-4)C Lesion in Complex with a (6-4) DNA Photolyase and Repair of UV-Induced (6-4) and Dewar Photolesions
  Snapshots of the Fluorosalinosporamide/20S Complex Offer Mechanistic Insights for Fine Tuning Proteasome Inhibition
  beta-Lactones Decrease the Intracellular Virulence of Listeria monocytogenes in
  Prolonged stability by cyclization: Macrocyclic phosphino dipeptide isostere inhibitors of ß-secretase (BACE1)
  A new ground state single electron donor for excess electron transfer studies in DNA
  Structure of Active IspH Enzyme from Escherichia coli Provides Mechanistic Insights into Substrate Reduction
  NMR Structure and Dynamics of the Engineered Fluorescein-Binding Lipocalin FluA Reveal Rigidification of β-Barrel and Variable Loops upon Enthalpy-Driven Ligand Binding
  Alpenforum 2009
  Structural biology of DNA photolyases and cryptochromes
  CIPSM-Harvard Young Scientists' Forum (YSF)
  Cinnamic aldehyde derived probes for the active site labelling of pathogenesis associated enzymes
  Interaction and conformational dynamics of membrane-spanning protein helices
  Stabilization of conformationally dynamic helices by covalently attached acyl chains
  Bilder von der CIPSM-Festveranstaltung im Deutschen Museum am 4. Mai 2009
  An engineered lipocalin specific for CTLA-4 reveals a combining site with structural and conformational features similar to antibodies
  CIPSM-Festveranstaltung im Deutschen Museum am 4. Mai 2009
  The archaeal cofactor F0 is a light-harvesting antenna chromophore in eukaryotes
  Design of anti- and pro-aggregation variants to assess the effects of methionine oxidation in human prion protein
  Natural product inhibitors of protein–protein interactions mediated by Src-family SH2 domains
  Synthetic and structural studies on syringolin A and B reveal critical determinants of selectivity and potency of proteasome inhibition
  Universal sample preparation method for proteome analysis
  Sequence-specific conformational dynamics of model transmembrane domains determines their membrane fusogenic function
  beta-Lactam Probes As Selective Chemical-Proteomic Tools for the Identification and Functional Characterization of Resistance Associated Enzymes in MRSA
  Copper-Free “Click” Modification of DNA via Nitrile Oxide-Norbornene 1,3-Dipolar Cycloaddition
  Protein Iodination by Click Chemistry
  CIPSM Movie online stream
  Allosteric Switches: Remote Controls for Proteins
  Unraveling the Secrets of Protein-Metabolite Interactions
  Imaging of integrin alpha-v-beta-3 expression in patients with malignant glioma by [18F] Galacto-RGD positron emission tomography
  High-Affinity Recognition of Lanthanide(III) Chelate Complexes by a Reprogrammed Human Lipocalin 2
  Phosphorothioation of Oligonucleotides Strongly Influences the Inhibition of Bacterial (M.HhaI) and Human(Dnmt1) DNA Methyltransferases
  Structurally Refined b-Lactones as Potent Inhibitors of Devastating Bacterial Virulence Factors
  Crystal structure analysis of DNA lesion repair and tolerance mechanisms
  A Pan-Specific Inhibitor of the Polo-Box Domains of Polo-like Kinases Arrests Cancer Cells in Mitosis
  Importin 8 Is a Gene Silencing Factor that Targets Argonaute Proteins to Distinct mRNAs
  Two-polymerase mechanisms dictate error-free and error-prone translesion DNA synthesis in mammals
  Formation of Organozincate Anions in LiCl-Mediated Zinc Insertion Reactions
  Controlled Nucleation of DNA Metallization

2008

  The persisting challenge of selective and specific proteasome inhibition
  Aggregation and Reactivity of Organozincate Anions Probed by Electrospray Mass Spectrometry
  Recognition and repair of UV lesions in loop structures of duplex DNA by DASH-type cryptochrome
  Identification of potential substrate proteins for the periplasmic Escherichia coli chaperone Skp
  CIPSM ist Ausgewählter Ort im Land der Ideen
  A Human snoRNA with MicroRNA-Like Functions
  Novel Diazirine-Containing DNA Photoaffinity Probes for the Investigation of DNA-Protein-Interactions
  Evidence for Insertional RNA Editing in Humans
  5'-triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma
  Complex patterns of histidine, hydroxylated amino acids and the GxxxG motif mediate high-affinity transmembrane domain interactions
  Crystal Structure and Mechanism of a DNA (6-4) Photolyase
  Structural determinants of MIF functions in CXCR2-mediated inflammatory and atherogenic leukocyte recruitment
  Leaving Groups Prolong the Duration of 20S Proteasome Inhibition and Enhance the Potency of Salinosporamides
  Azatryptophans endow proteins with intrinsic blue fluorescence
  Structural Analysis of Spiro b-Lactone Proteasome Inhibitors
  CIPSM-Researchers Stephan Sieber and Thomas Böttcher win the Innovation award 2008 of the BioRegions in Germany
  Beta-Lactones as Specific Inhibitors of ClpP Attenuate the Production of Extracellular Virulence Factors of Staphylococcus aureus
  Postsynthetic DNA Modification through the Copper-Catalyzed Azide–Alkyne Cycloaddition Reaction
  The 1.8-Å Crystal Structure of α1-Acid Glycoprotein (Orosomucoid) Solved by UV RIP Reveals the Broad Drug-Binding Activity of This Human Plasma Lipocalin
  Beta-Lactams as Selective Chemical Probes for the in Vivo Labeling of Bacterial Enzymes Involved in Cell Wall Biosynthesis, Antibiotic Resistance, and Virulence
  Hier geht was!
  Intracellular uptake and inhibitory activity of aromatic fluorinated amino acids in human breast cancer cells
  Convenient syntheses of homopropargylglycine
  Inhibition of transcription factors with small organic molecules
  Inhibition of transcription factors with small organic molecules
  Exploiting Cross-Amyloid Interactions To Inhibit Insulin Aggregation but not Function: Nanomolar Affinity Inhibition of Insulin Aggregation by an IAPP Mimic
  Biomimetic synthesis of the IDO inhibitors exiguamine A and B
  Sequence-Specific Conformational Flexibility of SNARE Transmembrane Helices Probed by Hydrogen/Deuterium Exchange
  Synthesis and properties of DNA containing a spore photoproduct analog
  Fpg (MutM) recognizes bulky N7-substituted-FapydG lesion using a novel and unproductive binding mode
  Synthesis of a Stabilized Version of the Imidazolone DNA Lesion
  Ubiquitin docking at the proteasome through a novel pleckstrin-homology domain interaction
  Docking of tryptophan analogs to trytophanyl-tRNA synthetase: implications for non-canonical amino acid incorporations
  A high-throughput assay based on fluorescence polarization for inhibitors of the polo-box domain of polo-like kinase
  Inhibition of Polo-like Kinase 1 by Blocking Polo-Box Domain-Dependent Protein-Protein Interactions
  Signal Transducers and Activators of Transcription as Targets for Small Organic Molecules
  Temperature and pressure dependence of protein stability: The engineered fluorescein-binding lipocalin FluA shows an elliptic phase diagram
  A plant pathogen virulence factor inhibits the eukaryotic proteasome by a novel mechanism
  beta-Lactones as Privileged Structures for the Active-Site Labeling of Versatile Bacterial Enzyme Classes
  Efficient N-Terminal Glycoconjugation of Proteins by the N-End Rule
  DIRK TRAUNER: HE IS BACK!
  Synthetic Biology of Proteins: Tuning GFPs Folding and Stability with Fluoroproline
  Bayer Schering Pharma and CIPSM sign a strategic partnership
  Discovery of Chromone-Based Inhibitors of the Transcription Factor STAT5
  Synthesis of DNA Dumbbell Based Inhibitors for the Human DNA Methyltransferase Dnmt1
  A high-throughput assay for signal transducer and activator of transcription 5b based on fluorescence polarization
  Dissecting the Differences between the a and b Anomers of the Oxidative DNA Lesion FaPydG
  The carbohydrate recognition domain of Langerin reveals high structural similarity with the one of DC-SIGN but an additional, calcium-independent sugar-binding site

2007

  Selective Detection of 5-Methylcytosine Sites in DNA
  Secondary structure and distribution of fusogenic LV-peptides in lipid membranes
  CIPSM-Speaker Thomas Carell wins 2008 Otto-Bayer-Preis
  Nature Spotlight on Germany
  Seeing Cisplatin - Discerning how an anticancer drug meddles with replication, transcription
  Mechanism of transcriptional stalling at cisplatindamaged DNA
  Bypass of DNA Lesions Generated During Anticancer Treatment with Cisplatin by DNA Polymerase Eta
  In Vivo Chemoenzymatic Control of N-Terminal Processing in Recombinant Human Epidermal Growth Factor
  Structural Insight into the Dual Ligand Specificity and Mode of High Density Lipoprotein Association of Apolipoprotein D
  miRNAs Get an Early Start on Translational Silencing
  Phenylalanine Promotes Interaction of Transmembrane Domains via GxxxG Motifs
  The Strep-tag system for one-step purification and high-affinity detection or capturing of proteins
  CPD Damage Recognition by Transcribing RNA Polymerase II




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TU München
MPG
Helmholz Muenchen
MPI of Neurobiology
MPI of Biochemistry