Research Area F

2013

  Making Waves: Initiation and Propagation of Corticothalamic Ca2+ Waves In Vivo
  Odorant-evoked electrical responses in Grueneberg ganglion neurons rely on cGMP-associated signaling proteins
  Cellular, subcellular and functional in vivo labeling of the spinal cord using vital dyes
  Up-regulation of Hyperpolarization-activated Cyclic Nucleotide-gated Channel 3 (HCN3) by Specific Interaction with K+ Channel Tetramerization Domain-containing Protein 3 (KCTD3)
  Structural Properties of Model Phosphatidylcholine Flippases
  Sequential Photo-bleaching to Delineate Single Schwann Cells at the Neuromuscular Junction

2012

  The Backbone Dynamics of the Amyloid Precursor Protein Transmembrane Helix Provides a Rationale for the Sequential Cleavage Mechanism of γ‑Secretase
  Characterization of neurite outgrowth and ectopic synaptogenesis in response to photoreceptor dysfunction
  In Vivo Imaging of Disease-Related Mitochondrial Dynamics in a Vertebrate Model System
  Isotope-Based Analysis of Modified tRNA Nucleosides Correlates Modification Density with Translational Efficiency
  LOTOS-based two-photon calcium imaging of dendritic spines in vivo
  Complex Regulation of Voltage-dependent Activation and Inactivation Properties of Retinal Voltage-gated Cav1.4 L-type Ca2+ Channels by Ca2+-binding Protein 4 (CaBP4)
  Biocompatibility of a genetically encoded calcium indicator in a transgenic mouse model
  Gene Therapy Restores Vision and Delays Degeneration in the CNGB1-/- Mouse Model of Retinitis Pigmentosa
  Dendritic spines: from structure to in vivo function
  Regulation of Hyperpolarization-activated Cyclic Nucleotide-gated (HCN) Channel Activity by cCMP
  Critical role of soluble amyloid-β for early hippocampal hyperactivity in a mouse model of Alzheimer’s disease
  Role of TRPML and Two-Pore Channels in Endolysosomal Cation Homeostasis
  Staged decline of neuronal function in vivo in an animal model of Alzheimer's disease
  Endoplasmic Reticulum Stress-associated Cone Photoreceptor Degeneration in Cyclic Nucleotide-gated Channel Deficiency
  Imaging Calcium in Neurons
  Axonal transport deficits and degeneration can evolve independently in mouse models of amyotrophic lateral sclerosis
  CNGA3 Deficiency Affects Cone Synaptic Terminal Structure and Function and Leads to Secondary Rod Dysfunction and Degeneration

2011

  Exploring HCN channels as novel drug targets
  The Role of HCN Channels in Ventricular Repolarization
  Spatial constraints dictate glial territories at murine neuromuscular junctions
  Chemo- and Thermosensory Responsiveness of Grueneberg Ganglion Neurons Relies on Cyclic Guanosine Monophosphate Signaling Elements
  Dendritic coding of multiple sensory inputs in single cortical neurons in vivo
  Development of Direction Selectivity in Mouse Cortical Neurons
  CNGA3: A Target of Spinal Nitric Oxide/cGMP Signaling and Modulator of Inflammatory Pain Hypersensitivity
  Functional mapping of single spines in cortical neurons in vivo
  Near-infrared branding efficiently correlates light and electron microscopy
  In vivo imaging reveals a phase-specific role of STAT3 during central and peripheral nervous system axon regeneration
  A reversible form of axon damage in experimental autoimmune encephalomyelitis and multiple sclerosis
  Attenuated Abeta42 responses to low potency gamma-secretase modulators can be overcome for many pathogenic presenilin mutants by second-generation compounds
  The cGMP-Dependent Protein Kinase II Is an Inhibitory Modulator of the Hyperpolarization-Activated HCN2 Channel
  Rescue of Progranulin Deficiency Associated with Frontotemporal Lobar Degeneration by Alkalizing Reagents and Inhibition of Vacuolar ATPase
  mGluR1/TRPC3-mediated Synaptic Transmission and Calcium Signaling in Mammalian Central Neurons
  A key role for cyclic nucleotide gated (CNG) channels in cGMP-related retinitis pigmentosa
  In vivo two-photon imaging of sensory-evoked dendritic calcium signals in cortical neurons
  HCN2 channels in local inhibitory interneurons constrain LTP in the hippocampal direct perforant path
  The Glutamic Acid-Rich Protein Is a Gating Inhibitor of Cyclic Nucleotide-Gated Channels

2010

  Tissue Distribution of 5-Hydroxymethylcytosine and Search for Active Demethylation Intermediates
  Planar Patch Clamp Approach to Characterize Ionic Currents from Intact Lysosomes
  Restoration of Cone Vision in the CNGA3−/− Mouse Model of Congenital Complete Lack of Cone Photoreceptor Function
  Inhibition of mitochondrial fusion by Alpha-synuclein is rescued by PINK1 Parkin and DJ-1
  Altered synaptic plasticity and behavioral abnormalities in CNGA3-deficient mice
  Transmembrane Protein 147 (TMEM147) Is a Novel Component of the Nicalin-NOMO Protein Complex
  Quantification of the Sixth DNA Base Hydroxymethylcytosine in the Brain
  An Olfactory Subsystem that Detects Carbon Disulfide and Mediates Food-Related Social Learning
  ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import
  Disruption of the olivo-cerebellar circuit by Purkinje neuron-specific ablation of BK channels
  Bepridil and Amiodarone Simultaneously Target the Alzheimer's Disease beta - and gamma-Secretase via Distinct Mechanisms
  Genetic Reactivation of Cone Photoreceptors Restores Visual Responses in Retinitis Pigmentosa
  Three-Amino Acid Spacing of Presenilin Endoproteolysis Suggests a General Stepwise Cleavage of gamma-Secretase-Mediated Intramembrane Proteolysis
  Grueneberg Ganglion Neurons Are Finely Tuned Cold Sensors
  Induction of STAT3-related genes in fast degenerating cone photoreceptors of cpfl1 mice
  Christian Haass received an honorary doctorate from the University of Zurich
  Dendritic organization of sensory input to cortical neurons in vivo
  Methylene blue fails to inhibit Tau and polyglutamine protein-dependent toxicity in zebrafish
  Expression of the anti-amyloidogenic secretase ADAM10 is suppressed by its 5′-untranslated region
  Beta-amyloid precursor protein mutants respond to gamma-secretase modulators
  Transgenic Zebrafish as a Novel Animal Model to Study Tauopathies and Other Neurodegenerative Disorders in vivo
  The cyclic nucleotide-gated ion channel CNGA3 contributes to coolness-induced responses of Grueneberg ganglion neurons
  Rapid time course of action potentials in spines and remote dendrites of mouse visual cortex neurons
  The Retinitis Pigmentosa Mutation c.3444+1G>A in CNGB1 Results in Skipping of Exon 32
  In Vivo Analysis of Cone Survival in Mice

2009

  Requirement for Small Side Chain Residues within the GxGD-Motif of Presenilin for gamma-Secretase Substrate Cleavage
  Adult generation of glutamatergic olfactory bulb interneurons
  AP2gamma regulates basal progenitor fate in a region- and layer-specific manner in the developing cortex
  Activity-dependent plasticity of developing climbing fiber–Purkinje cell synapses
  Calmodulin is a functional regulator of CAV1.4 l-type CA2+ channels
  Hyperpolarization-Activated Cation Channels: From Genes to Function
  Sparsification of neuronal activity in the visual cortex at eye-opening
  Cyclic Nucleotide-Gated Channels
  The two-pore channel TPCN2 mediates NAADP-dependent Ca2+-release from lysosomal stores
  Proteolytic processing of TAR DNA binding protein-43 by caspases produces C-terminal fragments with disease defining properties independent of progranulin.
  Conditional Deletion of ß1-Integrin in Astroglia Causes Partial Reactive Gliosis
  A zebrafish model of tauopathy allows in vivo imaging of neuronal cell death and drug evaluation
  Cyclic Nucleotide-regulated Cation Channels
  Substrate Requirements for SPPL2b-dependent Regulated Intramembrane Proteolysis
  HCN channels : Structure, cellular regulation and physiological function
  Vasculature Guides Migrating Neuronal Precursors in the Adult Mammalian Forebrain via Brain-Derived Neurotrophic Factor Signaling
  Purification, Pharmacological Modulation, and Biochemical Characterization of Interactors of Endogenous Human γ-Secretase
  Vision tests in the mouse: Functional phenotyping with electroretinography

2008

  Chemical Cross-linking Provides a Model of the y-Secretase Complex Subunit Architecture and Evidence for Close Proximity of the C-terminal Fragment of Presenilin with APH-1
  Identification of neural progenitor pools by E(Spl) factors in the embryonic and adult brain
  Ex vivo imaging of motor axon dynamics in murine triangularis sterni explants
  MicroRNA-9 directs late organizer activity of the midbrain-hindbrain boundary
  Axonal Projections Originating From Raphe Serotonergic Neurons in the Developing and Adult Zebrafish, Danio rerio, Using Transgenics To Visualize Raphe-Specific pet1 Expression
  Mechanisms of metabotropic glutamate receptor-mediated synaptic signalling in cerebellar Purkinje cells
  Comparative Analysis of Serotonin Receptor (HTR1A/HTR1B Families) and Transporter (slc6a4a/b) Gene Expression in the Zebrafish Brain
  Progeny of Olig2-Expressing Progenitors in the Gray and White Matter of the Adult Mouse Cerebral Cortex
  Clusters of Hyperactive Neurons Near Amyloid Plaques in a Mouse Model of Alzheimer’s Disease
  Lysosomal Activity Associated with Developmental Axon Pruning
  Intramembrane Proteolysis of GxGD-type Aspartyl Proteases is slowed by a Familial Alzheimer Disease-like Mutation
  Gsk3β/PKA and Gli1 regulate the maintenance of neural progenitors at the midbrain-hindbrain boundary in concert with E(Spl) factor activity
  TRPC3 Channels Are Required for Synaptic Transmission and Motor Coordination
  NR4A2 controls the differentiation of selective dopaminergic nuclei in the zebrafish brain
  Fgf signaling in the zebrafish adult brain: Association of Fgf activity with ventricular zones but not cell proliferation
  Intramembrane Proteolysis by gamma-Secretase
  Regulatory RNA goes awry in Alzheimer’s disease
  Development of Presynaptic Inhibition Onto Retinal Bipolar Cell Axon Terminals Is Subclass-Specific
  A Novel Sorting Nexin Modulates Endocytic Trafficking and alpha-Secretase Cleavage of the Amyloid Precursor Protein
  The two faces of protein misfolding: gain- and loss-of-function in neurodegenerative diseases
  Prospective isolation of functionally distinct radial glial subtypes—Lineage and transcriptome analysis
  Homosynaptic Long-Term Synaptic Potentiation of the "Winner" Climbing Fiber Synapse in developing Purkinje Cells
  Adult Neurogenesis Requires Smad4-Mediated Bone Morphogenic Protein Signaling in Stem Cells

2007

  Loss-of-Function of Human PINK1 Results in Mitochondrial Pathology and Can Be Rescued by parkin
  FTLD-U linked missense mutations in the progranulin gene reduce progranulin production and secretion
  Regulated Intramembrane Proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/b
  Generation of Aß38 and Aß42 is independendently and differentially affected by FAD-associated presenilin mutations and gamma-secretase modulation
  Function and Dysfunction of CNG Channels: Insights from Channelopathies and Mouse Models
  Contribution of the receptor guanylyl cyclase GC-D to chemosensory function in the olfactory epithelium
  Active gamma-secretase complexes contain only one of each component
  Endoplasmic reticulum retetion of the gamma-secretase complex component Pen2 by Rer1
  The Nicastrin-like Protein Nicalin Regulates Assembly and Stability of the Nicalin-Nodal Modulator (NOMO) Membrane Protein Complex




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LMUexcellent
TU München
MPG
Helmholz Muenchen
MPI of Neurobiology
MPI of Biochemistry