Research Area F

2010

  Bepridil and Amiodarone Simultaneously Target the Alzheimer's Disease beta - and gamma-Secretase via Distinct Mechanisms
  Christian Haass received an honorary doctorate from the University of Zurich
  Dendritic organization of sensory input to cortical neurons in vivo
  Methylene blue fails to inhibit Tau and polyglutamine protein-dependent toxicity in zebrafish
  APP Mutants Respond to γ-Secretase Modulators
  Expression of the anti-amyloidogenic secretase ADAM10 is suppressed by its 5′-untranslated region
  Beta-amyloid precursor protein mutants respond to gamma-secretase modulators
  Rapid time course of action potentials in spines and remote dendrites of mouse visual cortex neurons

2009

  Requirement for Small Side Chain Residues within the GxGD-Motif of Presenilin for gamma-Secretase Substrate Cleavage
  Adult generation of glutamatergic olfactory bulb interneurons
  AP2gamma regulates basal progenitor fate in a region- and layer-specific manner in the developing cortex
  Activity-dependent plasticity of developing climbing fiber–Purkinje cell synapses
  Calmodulin is a functional regulator of CAV1.4 l-type CA2+ channels
  Hyperpolarization-Activated Cation Channels: From Genes to Function
  Sparsification of neuronal activity in the visual cortex at eye-opening
  Cyclic Nucleotide-Gated Channels
  The two-pore channel TPCN2 mediates NAADP-dependent Ca2+-release from lysosomal stores
  Proteolytic processing of TAR DNA binding protein-43 by caspases produces C-terminal fragments with disease defining properties independent of progranulin.
  Conditional Deletion of ß1-Integrin in Astroglia Causes Partial Reactive Gliosis
  A zebrafish model of tauopathy allows in vivo imaging of neuronal cell death and drug evaluation
  Cyclic Nucleotide-regulated Cation Channels
  Substrate Requirements for SPPL2b-dependent Regulated Intramembrane Proteolysis
  HCN channels : Structure, cellular regulation and physiological function
  Vasculature Guides Migrating Neuronal Precursors in the Adult Mammalian Forebrain via Brain-Derived Neurotrophic Factor Signaling
  Purification, Pharmacological Modulation, and Biochemical Characterization of Interactors of Endogenous Human γ-Secretase
  Vision tests in the mouse: Functional phenotyping with electroretinography

2008

  Chemical Cross-linking Provides a Model of the y-Secretase Complex Subunit Architecture and Evidence for Close Proximity of the C-terminal Fragment of Presenilin with APH-1
  Identification of neural progenitor pools by E(Spl) factors in the embryonic and adult brain
  Ex vivo imaging of motor axon dynamics in murine triangularis sterni explants
  MicroRNA-9 directs late organizer activity of the midbrain-hindbrain boundary
  Axonal Projections Originating From Raphe Serotonergic Neurons in the Developing and Adult Zebrafish, Danio rerio, Using Transgenics To Visualize Raphe-Specific pet1 Expression
  Mechanisms of metabotropic glutamate receptor-mediated synaptic signalling in cerebellar Purkinje cells
  Comparative Analysis of Serotonin Receptor (HTR1A/HTR1B Families) and Transporter (slc6a4a/b) Gene Expression in the Zebrafish Brain
  Progeny of Olig2-Expressing Progenitors in the Gray and White Matter of the Adult Mouse Cerebral Cortex
  Clusters of Hyperactive Neurons Near Amyloid Plaques in a Mouse Model of Alzheimer’s Disease
  Lysosomal Activity Associated with Developmental Axon Pruning
  Intramembrane Proteolysis of GxGD-type Aspartyl Proteases is slowed by a Familial Alzheimer Disease-like Mutation
  Gsk3β/PKA and Gli1 regulate the maintenance of neural progenitors at the midbrain-hindbrain boundary in concert with E(Spl) factor activity
  TRPC3 Channels Are Required for Synaptic Transmission and Motor Coordination
  NR4A2 controls the differentiation of selective dopaminergic nuclei in the zebrafish brain
  Fgf signaling in the zebrafish adult brain: Association of Fgf activity with ventricular zones but not cell proliferation
  Intramembrane Proteolysis by gamma-Secretase
  Regulatory RNA goes awry in Alzheimer’s disease
  Development of Presynaptic Inhibition Onto Retinal Bipolar Cell Axon Terminals Is Subclass-Specific
  A Novel Sorting Nexin Modulates Endocytic Trafficking and alpha-Secretase Cleavage of the Amyloid Precursor Protein
  The two faces of protein misfolding: gain- and loss-of-function in neurodegenerative diseases
  Prospective isolation of functionally distinct radial glial subtypes—Lineage and transcriptome analysis
  Homosynaptic Long-Term Synaptic Potentiation of the "Winner" Climbing Fiber Synapse in developing Purkinje Cells
  Adult Neurogenesis Requires Smad4-Mediated Bone Morphogenic Protein Signaling in Stem Cells

2007

  Loss-of-Function of Human PINK1 Results in Mitochondrial Pathology and Can Be Rescued by parkin
  FTLD-U linked missense mutations in the progranulin gene reduce progranulin production and secretion
  Regulated Intramembrane Proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/b
  Generation of Aß38 and Aß42 is independendently and differentially affected by FAD-associated presenilin mutations and gamma-secretase modulation
  Function and Dysfunction of CNG Channels: Insights from Channelopathies and Mouse Models
  Contribution of the receptor guanylyl cyclase GC-D to chemosensory function in the olfactory epithelium
  Active gamma-secretase complexes contain only one of each component
  Endoplasmic reticulum retetion of the gamma-secretase complex component Pen2 by Rer1
  The Nicastrin-like Protein Nicalin Regulates Assembly and Stability of the Nicalin-Nodal Modulator (NOMO) Membrane Protein Complex




LMUexcellent
TU München
MPG
Helmholz Muenchen
MPI of Neurobiology
MPI of Biochemistry