DNA Double-Strand Breaks Come into Focus

Cell, 2009, 139, 25-27, doi:10.1016/j.cell.2009.09.017 published on 02.10.2009
Cell, online article
The Mre11-Rad50-Nbs1 (MRN) complex senses DNA double-strand breaks and recruits different repair pathway and checkpoint proteins to break foci. Two new studies (Williams et al., 2009; Lloyd et al., 2009,Williams et al., 2009; Lloyd et al., 2009) identify Nbs1 as a key factor in this process and reveal how an N-terminal protein recruitment module in Nbs1 binds to different response factors through shared phosphopeptide motifs.

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