Integrin modulators: a patent review

Expert Opin., 2013, doi:10.1517/13543776.2013.818133, Vol. 23, No. 10 , Pages 1273-1295 published on 15.10.2013
Expert Opin., online article
Integrins are heterodimeric cell surface receptors, which enable adhesion, proliferation, and migration of cells by recognizing binding motifs in extracellular matrix (ECM) proteins. As transmembrane linkers between the cytoskeleton and the ECM, they are able to recruit a huge variety of proteins and to influence signaling pathways bidirectionally, thereby regulating gene expression and cell survival. Hence, integrins play a key role in various physiological as well as pathological processes, which has turned them into an attractive target for pharmaceutical research.

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