NMR Spectroscopy of Soluble Protein Complexes at One Mega-Dalton and Beyond

Angewandte Chemie, 2013, DOI: 10.1002/anie.201301215, Volume 52, Issue 33, pages 8746–8751, published on 19.07.2013
Angewandte Chemie, online article
Solution-state nuclear magnetic resonance (NMR) spectroscopy is a very successful method to characterize the structure and dynamics of biomolecules in solution.[1, 2] However, resonance lines broaden significantly with increasing molecular weight, simultaneously affecting sensitivity and resolution. This broadening is due to long rotational tumbling correlation times tc, which enhance transverse relaxation.  

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