Telethonin Deficiency Is Associated With Maladaptation to Biomechanical Stress in the Mammalian Heart

Circulation Research, 2011, doi: 10.1161/​CIRCRESAHA.111.245787, 758-769 published on 28.07.2011

Circulation Research, online article

Telethonin (also known as titin-cap or t-cap) is a 19-kDa Z-disk protein with a unique beta-sheet structure, hypothesized to assemble in a palindromic way with the N-terminal portion of titin and to constitute a signalosome participating in the process of cardiomechanosensing. In addition, a variety of telethonin mutations are associated with the development of several different diseases; however, little is known about the underlying molecular mechanisms and telethonin’s in vivo function.

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