Emergence of cancer stem cells in hepatocellular carcinoma

The EMBO Journal, 2015, DOI: 10.15252/embj.201490785, Volume 34, Issue 4, pages 425–426, published on 08.01.2015
The EMBO Journal, online article
Liver cancer represents the second most deadly human malignancy. The major histological subtype called hepatocellular carcinoma (HCC) arises by chronic inflammation-triggered regenerative responses of normally quiescent hepatocytes and progenitors, respectively. Such regenerative stress accelerates the accumulation of genetic and epigenetic changes (Yamashita & Wang, 2013), while detailed mechanisms remain uncertain. In this issue of The EMBO Journal, Nikolaou et al present a novel HCC model that facilitates both isolation and molecular characterization of self-renewing, HCC-propagating cancer stem cells that could instruct future interventions (Nikolaou et al, 2014).  

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