The tumor suppressor p53 connects ribosome biogenesis to cell cycle control: a double-edged sword

Oncotarget, 2010, Vol. 1, issue 1, pages 43 – 47 published on 01.05.2010
Oncotarget, online article
Since its first description more than 30 years ago p53 has become a paradigm for a protein with versatile functions. P53 sensitizes a large variety of genetic alterations and has been entitled the guardian of the genome. Stabilization of p53 upon DNA damage is accompanied by a complex pattern of modifications, which ascertain the cellular response either in the direction of a reversible or irreversible cell cycle arrest or programmed cell death. More recently it became evident that p53 also responds to non-genotoxic cell stress, in particular if ribosome biogenesis is affected.

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