UNR facilitates the interaction of MLE with the lncRNA roX2 during Drosophila dosage compensation

Nature Communications, 2014, doi:10.1038/ncomms5762, 5, 4762 published on 27.08.2014
Nature Communications, online article
Dosage compensation is a regulatory process that balances the expression of X-chromosomal genes between males (XY) and females (XX). In Drosophila, this requires non-coding RNAs and RNA-binding proteins (RBPs) whose specific functions remain elusive. Here we show that the Drosophila RBP ​UNR promotes the targeting of the activating male-specific-lethal complex to the X-chromosome by facilitating the interaction of two crucial subunits: the RNA helicase ​MLE and the long non-coding RNA ​roX2.

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