Research Area E - Publications 2018

NATURE COMMUNICATIONS, 9:2510, https://doi.org/10.1038/s41467-018-04928-9
NATURE COMMUNICATIONS, online article

dube-gerwien_2018_naturecomm_550.100x0.jpeg

Photoisomerization reactions are quintessential processes driving molecular machines and motors, govern smart materials, catalytic processes, and photopharmacology, and lie at the heart of vision, phototaxis, or vitamin production. Despite this plethora of applications fundamental photoisomerization mechanisms are not well understood at present. The famous ...

|READ MORE|

ACS Synth. Biol., Article ASAP, DOI: 10.1021/acssynbio.8b00151
ACS Synth. Biol., online article

gulder_acssynbio_550.100x0.jpg

The need  for new pharmacological lead structures, especially against drug resistances, has led to a surge in natural product research and discovery. New biosynthetic gene cluster capturing methods to efficiently clone and heterologously express natural product pathways have thus been developed. Direct pathway cloning (DiPaC) is an emerging synthetic biology ...

|READ MORE|

Angew. Chem. Int. Ed., Volume 57, Issue 34, Pages 11064-11068, https://doi.org/10.1002/anie.201804716
Angew. Chem. Int. Ed., online article

dube-uhl_2018_acie_550.100x0.jpeg

Molecular motors undergo repetitive directional motions upon external energy input. A profound challenge is the defined transfer of directional motor motions to remote entities at the molecular scale. Herein, we present a molecular setup that allows for the transfer of the directional rotation of a light‐powered motor unit onto a remote biaryl axis via an ...

|READ MORE|

Molecular Cellular Proteomics, doi: 10.1074/mcp.TIR118.000783 mcp.TIR118.000783
Molecular Cellular Proteomics, online ablage

kuester-mol_cell_proteomics-2018-zolg-mcp_tir118_000783_550.100x0.jpeg

The analysis of the post-translational modification (PTM) state of proteins using mass spectrometry-based bottom-up proteomic workflows has evolved into a powerful tool for the study of cellular regulatory events that are not directly encoded at the genome level. Besides frequently detected modifications such as phosphorylation, acetylation and ubiquitination, ...

|READ MORE|

Angew. Chem. Int. Ed. 2018, 57, 1 – 5, https://doi.org/10.1002/anie.201802176
Angew. Chem. Int. Ed., online article

gulder-sib_et_al-2018-angewandte_chemie_international_edition_550.100x0.jpg

The sorbicillinoids are a large family of fungal natural products, many of which possess highly challenging molecular architectures. Depending on their individual structures they exhibit strong biological activities ranging from radical scavenging and anti‐infective properties to cytotoxicity. Despite the resulting strong biomedical potential of these natural ...

|READ MORE|

Mar. Drugs 2018, 16(5), 147; https://doi.org/10.3390/md16050147
Mar. Drugs, online article

gulder-marinedrugs-16-00147_550.100x0.jpeg

Actinomycetes are a relevant source of novel bioactive compounds. One of the pharmaceutically and biotechnologically important genera that attract natural products research is the genus Nocardiopsis, mainly for its ability to produce a wide variety of secondary metabolites accounting for its wide range of biological activities. This review covers the literature ...

|READ MORE|

Acc. Chem. Res., 2018, 51 (5), pp 1153–1163, DOI: 10.1021/acs.accounts.7b00638
Acc. Chem. Res., online article

dube-petermayer_2018_accchemres_550.100x0.jpeg

Indigoid photoswitches comprise a class of chromophores that are derived from the parent and well-known indigo dye. Different from most photoswitches their core structures absorb in the visible region of the spectrum in both isomeric states even without substitutions, which makes them especially interesting for applications not tolerant of high-energy UV light. ...

|READ MORE|

ChemPhotoChem 2018, 2, 1–8, https://doi.org/10.1002/cptc.201700228
ChemPhotoChem, online article

dube-huber_2018_chemphotochem_550.100x0.jpeg

Substituted indigo derivatives undergo photoisomerization of the central double bond if both nitrogen atoms are functionalized. Indigo itself however does not photoisomerize because of a competing and highly efficient excited‐state proton transfer. In this work, we show that also mono‐arylated indigo undergoes photoisomerization despite still possessing one ...

|READ MORE|

Nature Communications, volume 9, Article number: 1456 (2018), doi:10.1038/s41467-018-03912-7
Nature Communications, online article

dube-wiedbrauk_2018_natcommun_550.100x0.jpeg

Remote control of complex molecular behavior and function is one key problem in modern chemistry. Using light signaling for this purpose has many advantages, however the integration of different photo processes into a wholesome yet complex system is highly challenging. Here we report an alternative approach to increase complexity of light control-simultaneous ...

|READ MORE|

icem_550.100x0.gif

Wir freuen uns, dass der Bau unseres neuen CIPSM Gebäudes, das Institut für Chemische Epigenetik ICEM nun beginnt.

Damit Sie im Bilde sind und sich darauf einstellen können finden Sie hier die relevanten Eckdaten zur Baustelle Neubau ICEM:
 

1. Baustelleneinrichtung ab ca. 15.09.2017

2. Beginn Erdarbeiten/Spezialtiefbau ab ca. 30.09.2017

3. Beginn ...

|READ MORE|

J. Am. Chem. Soc., 2018, 140 (15), pp 5311–5318, DOI: 10.1021/jacs.8b02349
J. Am. Chem. Soc., online article

 

dube-wilcken_2018_jacs_550.100x0.jpeg

Hemithioindigo-based molecular motors are powered by nondamaging visible light and provide very fast directional rotations at ambient conditions. Their ground state energy profile has been probed in detail, but the crucial excited state processes are completely unknown so far. In addition, very fast processes in the ground state are also still elusive to date and ...

|READ MORE|

Metabolic Engineering, 47 (2018) 334–345, https://doi.org/10.1016/j.ymben.2018.03.010
Metabolic Engineering, online article

gulder-1-s2_0-s1096717618300247-main_550.100x0.jpeg

Specialized metabolites from bacteria are an important source of inspiration for drug development. The genes required for the biosynthesis of such metabolites in bacteria are usually organized in so-called biosynthetic gene clusters (BGCs). Using modern bioinformatic tools, the wealth of genomic data can be scanned for such BGCs and the expected products can ...

|READ MORE|

Phys. Chem. Chem. Phys., 2018,20, 6868-6876, DOI: 10.1039/C8CP00096D
Phys. Chem. Chem. Phys., online article

dube-navratil_2018_physchemchemphys_550.100x0.jpeg

Hemithioindigo compounds are attractive two-way molecular photoswitches combining stilbene and thioindigo parts connected by a C–C double bond. In solution, these photoswitches have been well studied. This study presents the investigation of a hemithioindigo derivative in the gas phase. Visible absorption spectra, measured by standard (visPD) and helium-tagging ...

|READ MORE|

Biochemistry, 2018, 57 (11), pp 1814–1820, DOI: 10.1021/acs.biochem.7b01271
Biochemistry, online article

 

sieber-10_1021acs_biochem_7b01271_550.100x0.jpeg

Staphylococcus aureus is a major bacterial pathogen that invades and damages host tissue by the expression of devastating toxins. We here performed a phenotypic screen of 35 molecules that were structurally inspired by previous hydroxyamide-based S. aureus virulence inhibitors compiled from commercial sources or designed and synthesized de novo. One of the most ...

|READ MORE|

Angew. Chem. Int. Ed., Volume 57, Issue 11, Pages 2754-2756, DOI: 10.1002/anie.201800629
Angew. Chem. Int. Ed., online article

gulder-gloeckle_et_al-2018-angewandte_chemie_international_edition_550.100x0.jpeg

All roads lead to Rome: The biosynthesis of the leporins in Aspergillus sp. involves an unprecedented pericyclic reaction cascade. The enzyme LepI directs the periselectivity of a [4+2] cycloaddition towards a hetero‐Diels–Alder reaction outcome to give the leporin molecular scaffold. The Diels–Alder side product is morphed into the leporin core structure by a ...

|READ MORE|

Nature Communications, 9, Article number: 163, doi:10.1038/s41467-017-02639-1
Nature Communications, online article

carell-becker_et_al-2018-nature_communications_550.100x0.jpeg

The molecules of life were created by a continuous physicochemical process on an early Earth. In this hadean environment, chemical transformations were driven by fluctuations of the naturally given physical parameters established for example by wet–dry cycles. These conditions might have allowed for the formation of (self)-replicating RNA as the fundamental ...

|READ MORE|

Angewandte Chemie International Edition, DOI: 10.1002/anie.201708867
Angewandte Chemie International Edition, online article

carell-stadlmeier_et_al-2018-angewandte_chemie_international_edition_550.100x0.jpeg

Modern proteomics requires reagents for exact quantification of peptides in complex mixtures. Peptide labelling is most typically achieved with isobaric tags that consist of a balancer and a reporter part that separate in the gas phase. An ingenious distribution of stable isotopes provides multiple reagents with identical molecular weight but a different mass of ...

|READ MORE|

J. Am. Chem. Soc., 2018, 140 (5), pp 1774–1782, DOI: 10.1021/jacs.7b11212
J. Am. Chem. Soc., online article

 

sieber-10_1021jacs_7b11212_550.100x0.jpeg

Natural products have served as an inspiration to scientists both for their complex three-dimensional architecture and exquisite biological activity. Promysalin is one such Pseudomonad secondary metabolite that exhibits narrow-spectrum antibacterial activity, originally isolated from the rhizosphere. We herein utilize affinity-based protein profiling (AfBPP) to ...

|READ MORE|

Nature Structural & Molecular Biology, volume 25,  90–100 (2018), doi:10.1038/s41594-017-0012-6
Nature Structural & Molecular Biology, online article

antes-lamb-buchner-nat_struct_mol_biol_2018_rosam_1_550.100x0.jpg

BiP is the endoplasmic member of the Hsp70 family. BiP is regulated by several co-chaperones including the nucleotide-exchange factor (NEF) Bap (Sil1 in yeast). Bap is a two-domain protein. The interaction of the Bap C-terminal domain with the BiP ATPase domain is sufficient for its weak NEF activity. However, stimulation of the BiP ATPase activity requires ...

|READ MORE|

CIPSM Movie
LMUexcellent
TU München
MPG
Helmholtz München
MPI of Neurobiology
MPI of Biochemistry