An Approach to Aminonaphthoquinone Ansamycins Using a Modified Danishefsky Diene

Org. Letters, 2012, DOI: 10.1021/ol203437a, published on 01.02.2012

Org. Letters, online article

A robust and scalable synthesis of a novel, cyano-substituted Danishefsky-type diene and its use in the Diels-Alder reaction with various dienophiles is reported. The diene allows for the rapid construction of highly substituted aminonaphthoquinones that occur in numerous ansamycin antibiotics.

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