Azo-Propofols: Photochromic Potentiators of GABAA Receptors

Angewandte Chemie, 2012, DOI: 10.1002/anie.201205475, Volume 51, Issue 42, pages 10500–10504 published on 11.09.2012

Angewandte Chemie, online article

GABAA receptors are pentameric ligand-gated ion channels that are activated by the major inhibitory neurotransmitter in the mammalian brain, g-aminobutyric acid (GABA).Binding of GABA results in the opening of a chloride ion selective pore, thus hyperpolarizing the postsynaptic neuron and decreasing the likelihood of action-potential firing. As such, GABAA receptors are a prominent target for anesthetic, hypnotic, and anticonvulsant drugs.  

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