Self-interaction of transmembrane helices representing pre-clusters from the human single-span membrane proteins

Bioinformatics, 2013, doi: 10.1093/bioinformatics/btt247, pages 1–8 published on 01.05.2013
Bioinformatics, online article
Most integral membrane proteins form dimeric or oligomeric complexes. Oligomerization is frequently supported by the non-covalent interaction of transmembrane helices. It is currently not clear how many high-affinity transmembrane domains (TMD) exist in a proteome and how specific their interactions are with respect to preferred contacting faces and their underlying residue motifs.  

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