Cascaded Photoinduced Drug Delivery to Cells from Multifunctional Core–Shell Mesoporous Silica

Advanced Healthcare Materials, 2012, DOI: 10.1002/adhm.201100033, Volume 1, Issue 3, pages 316–320 published on 02.05.2012
Advanced Healthcare Materials, online article
Different bioactive molecules are released into living cells from lipid-covered mesoporous silica nanoparticles. The release is triggered by light, as the particles feature covalently attached photosensitizers as membrane-opening agents. It is demonstrated that the particles achieve endosomal escape and that they release their cargo into the cytosol.

TU München
Helmholtz München
MPI of Neurobiology
MPI of Biochemistry