Controlling the Structure of Proteins at Surfaces

JACS, 2010, doi:10.1021/ja107212z, published on 16.11.2010
JACS, online article
With the help of single molecule force spectroscopy and molecular dynamics simulations, we determine the surface-induced structure of a single engineered spider silk protein. An amyloid like structure is induced in the vicinity of a surface with high surface energy and can be prohibited in the presence of a hydrophobic surface. The derived molecular energy landscapes highlight the role of single silk protein structure for the macroscopic toughness of spider silk.

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