Differential pH-dependent cellular uptake pathways among foamy viruses elucidated using dual-colored fluorescent particles

Retrovirology, 2012, doi:10.1186/1742-4690-9-71, 9:71 published on 30.08.2012
Retrovirology, online article
It is thought that foamy viruses (FVs) enter host cells via endocytosis because all FV glycoproteins examined display pH-dependent fusion activities. Only the prototype FV (PFV) glycoprotein has also significant fusion activity at neutral pH, suggesting that its uptake mechanism may deviate from other FVs. To gain new insights into the uptake processes of FV in individual live host cells, we developed fluorescently labeled infectious FVs.  

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TU München
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Helmholtz München
MPI of Neurobiology
MPI of Biochemistry