Mechanism of UV-Induced Formation of Dewar Lesions in DNA

Angewandte Chemie, 2011, DOI: 10.1002/anie.201106231, Volume 51, Issue 2, pages 408–411, published on 09.01.2012
Angewandte Chemie, online article
Living organisms exposed to sunlight are constantly challenged by the formation of UV-induced lesions in DNA, which induce cell death and cause mutations. UVirradiation of TpT and TpC sequences leads to the formation of two primary lesions, namely cyclobutane-pyrimidine dimers (CPD)and lesions, as depicted in Scheme 1. These lesions possess an additional absorption at lmax=320 nm and rearrange to give Dewar valence isomers.

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