Regulation of a heterodimeric kinesin-2 through an unprocessive motor domain that is turned processive by its partner

PNAS, 2010, doi/10.1073/pnas.1005177107, published on 17.05.2010, online article
Speedy couriers in the cell. Every single one of our cells contains so-called motor proteins that transport important substances from one location to another. However, very little is known about how exactly these transport processes occur. Biophysicists at CIPSM have now succeeded in explaining fundamental functions of a particularly interesting motor protein. Motorized transport proteins are one of the keys to the development of higher organisms. It is they that enable the cell to transport important substances directly and quickly to a specific location in the cell. As bacteria cannot do this, they are not able to form larger cells or even large organisms with many cells. Particularly important are fast transport proteins in the primary cilia, the cell’s antennas, with which they channel information from the surroundings into the cell.  

TU München
Helmholtz München
MPI of Neurobiology
MPI of Biochemistry