Conservation between the RNA Polymerase I, II, and III Transcription Initiation Machineries

Molecular Cell, 2012, DOI 10.1016/j.molcel.2012.01.023, published on 23.02.2012

Molecular Cell, online article

Recent studies of the three eukaryotic transcription machineries revealed that all initiation complexes share a conserved core. This core consists of the RNA polymerase (I, II, or III), the TATA box-binding protein (TBP), and transcription factors TFIIB, TFIIE, and TFIIF (for Pol II) or proteins structurally and functionally related to parts of these factors (for Pol I and Pol III). The conserved core initiation complex stabilizes the open DNA promoter complex and directs initial RNA synthesis. The periphery of the core initiation complex is decorated by additional polymerase-specific factors that account for functional differences in promoter recognition and opening, and gene class-specific regulation. This review outlines the similarities and differences between these important molecular machines.

TU München
Helmholtz München
MPI of Neurobiology
MPI of Biochemistry