Dynamics in the solid-state: perspectives for the investigation of amyloid aggregates, membrane proteins and soluble protein complexes

Journal of Biomolecular NMR, 2014, DOI 10.1007/s10858-014-9822-6, Volume 59, Issue 1, pp 1-14 published on 05.03.2014
Journal of Biomolecular NMR, online article
Aggregates formed by amyloidogenic peptides and proteins and reconstituted membrane protein preparations differ significantly in terms of the spectral quality that they display in solid-state NMR experiments. Structural heterogeneity and dynamics can both in principle account for that observation. This perspectives article aims to point out challenges and limitations, but also potential opportunities in the investigation of these systems  

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