Improvement of drug-like properties of peptides: the somatostatin paradigm

informa healthcare, 2010, Vol. 5, No. 7 , Pages 655-671, doi:10.1517/17460441.2010.493935 published on 15.07.2010

informa healthcare, online article

Importance of the field: Peptides are promising candidates as therapeutic agents due to their wide involvement in physiological processes. However, their often non-selective activity and their poor drug-like properties, mainly their inherent low stability to enzymatic degradation and poor oral bioavailability, limit their clinical potential. Somatostatin is a peptide hormone involved in many different biological functions. The role of its five different receptor subtypes and their interplay in medicinal processes is only partially understood. In addition, it suffers from poor drug-like properties.  

TU München
Helmholtz München
MPI of Neurobiology
MPI of Biochemistry