Ribosome-targeting antibiotics and mechanisms of bacterial resistance

Nature Reviews Microbiology, 2014, doi:10.1038/nrmicro3155, 12, 35–48 published on 10.01.2014
Nature Reviews Microbiology, online article
The ribosome is one of the main antibiotic targets in the bacterial cell. Crystal structures of naturally produced antibiotics and their semi-synthetic derivatives bound to ribosomal particles have provided unparalleled insight into their mechanisms of action, and they are also facilitating the design of more effective antibiotics for targeting multidrug-resistant bacteria. In this Review, I discuss the recent structural insights into the mechanism of action of ribosome-targeting antibiotics and the molecular mechanisms of bacterial resistance, in addition to the approaches that are being pursued for the production of improved drugs that inhibit bacterial protein synthesis.

TU München
Helmholtz München
MPI of Neurobiology
MPI of Biochemistry