Research Area B - Publications 2018

Science, 360, 215–219, DOI: 10.1126/science.aar7899
Science, online article

braunger_beckmann_science_2018_550.100x0.jpeg

Protein synthesis, transport and N-glycosylation are coupled at the mammalian endoplasmic reticulum (ER) by complex formation between the ribosome, the Sec61 protein-conducting channel and the oligosaccharyltransferase (OST). Here, we used different cryo-electron microscopy approaches to determine structures of native and solubilized ribosome-Sec61-OST complexes. ...

|READ MORE|

Essays In Biochemistry, 62(1) 65-75; DOI: 10.1042/EBC20170093
Essays In Biochemistry, online article

soll-structural_components_involved_in_plastid_protein_import_550.100x0.jpeg

Import of preproteins into chloroplasts is an essential process, requiring two major multisubunit protein complexes that are embedded in the outer and inner chloroplast envelope membrane. Both the translocon of the outer chloroplast membrane (Toc), as well as the translocon of the inner chloroplast membrane (Tic) have been studied intensively with respect to ...

|READ MORE|

Int. J. Mol. Sci. 2018, 19(2), 641; doi:10.3390/ijms19020641
Int. J. Mol. Sci., online article

soll-plant_mitochondrial_inner_membrame_protein_insertion_550.100x0.jpeg

During the biogenesis of the mitochondrial inner membrane, most nuclear-encoded inner membrane proteins are laterally released into the membrane by the TIM23 and the TIM22 machinery during their import into mitochondria. A subset of nuclear-encoded mitochondrial inner membrane proteins and all the mitochondrial-encoded inner membrane proteins use the Oxa ...

|READ MORE|

Mitochondrion, https://doi.org/10.1016/j.mito.2018.01.005
Mitochondrion, online ablage

jung-soll-phosphorylation_of_the_outer_membrane_mitochondrial_protein_om64_influences_protein_import_into_mitochondria_550.100x0.jpeg

Mitochondrial localized proteins are mostly synthesized in the cytosol and translocated across the outer mitochondrial membrane via the translocase of the outer membrane (TOM) complex. Although the channel protein is conserved among eukaryotes, the receptor proteins are more divergent and show features specific to the plant lineage. OM64, which is a paralogue of ...

|READ MORE|

Nature Structural & Molecular Biology, volume 25,  90–100 (2018), doi:10.1038/s41594-017-0012-6
Nature Structural & Molecular Biology, online article

antes-lamb-buchner-nat_struct_mol_biol_2018_rosam_1_550.100x0.jpg

BiP is the endoplasmic member of the Hsp70 family. BiP is regulated by several co-chaperones including the nucleotide-exchange factor (NEF) Bap (Sil1 in yeast). Bap is a two-domain protein. The interaction of the Bap C-terminal domain with the BiP ATPase domain is sufficient for its weak NEF activity. However, stimulation of the BiP ATPase activity requires ...

|READ MORE|

CIPSM Movie
LMUexcellent
TU München
MPG
Helmholtz München
MPI of Neurobiology
MPI of Biochemistry