A Photochromic Agonist of AMPA Receptors
19-Apr-2012
Angewandte Chemie, 2012, DOI: 10.1002/anie.201109265, Volume 51, Issue 23, pages 5748–5751 published on 19.04.2012
Light switch: A photochromic agonist ATA-3 (see scheme) of AMPA receptors, arguably the most important class of ionotropic glutamate receptors, is shown to be subtype selective, activates the AMPA receptor GluA2 in the dark, and is quickly turned off when irradiated with blue–green light. It can be used to effectively control neuronal activity in the mammalian brain.