Crystal Structure of a Cisplatin-(1,3-GTG) Cross-Link within DNA Polymerase eta

Angew. Chem. Intl. Ed., 2010, 49 (17), 3077-3080, doi: 10.1002/anie.201000414 published on 23.03.2010
Angewandte Chemie International Edition, online article
Flipped out: The cisplatin-(1,3-GTG) adduct, a strongly cytotoxic DNA lesion generated by the action of cisplatin therapeutics, is partially bypassed by Y-family DNA polymerase . Crystal structure data on this DNA-protein complex explain the partial-bypass process. The central dT unit of the lesion is turned out and blocks the movement of the enzyme along the DNA duplex.

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