Exploring the Pharmacology and Action Spectra of Photochromic Open-Channel Blockers

ChemBioChem, 2012, DOI: 10.1002/cbic.201200216, Volume 13, Issue 12, pages 1746–1749 published on 13.07.2012

ChemBioChem, online article

Light control of voltage-gated ion channels: We have developed red-shifted derivatives of QAQ, a powerful doubly charged photochromic blocker. These derivatives allow for remote control of Kv and Nav channel conductance with light and offer the opportunity to silence neuronal activity reversibly.

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