Structurally Refined b-Lactones as Potent Inhibitors of Devastating Bacterial Virulence Factors
10-Feb-2009
With decreasing efficiency of antibiotic therapies against hospital- and community-acquired bacterial pathogens, the treatment of infectious diseases again represents a tremendous challenge for medicinal research. This challenge seems to be particularly difficult if one considers the sophisticated resistance strategies, which are effective against almost all currently available antibiotics, developed by bacterial pathogens, such as Staphylococcus aureus.