Navigating the Folding Energy Landscape of Green Fluorescent Protein

Angewandte Chemie International Edition, 2008, DOI: 10.1002/anie.200802987, Volume 47, Issue 43, pages 8192–8195, published on 11.09.2008
Angewandte Chemie International Edition, online article
The directed application of force to different points on the surface of the green fluorescent protein (GFP) makes it possible to shift between two different pathways with distinct unfolding intermediates. One pathway resembles a “folding-like” pathway, whereas the other may play a role during processes such as import through a pore. The picture shows the energy landscape of GFP with intermediates and pathways.  

TU München
Helmholtz München
MPI of Neurobiology
MPI of Biochemistry