Research Area A - Publications 2019

bioRxiv, doi: https://doi.org/10.1101/775528
bioRxiv, online article

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The TATA-binding protein (TBP) and a transcription factor (TF) IIB-like factor compound the fundamental core of all eukaryotic initiation complexes. The reason for the emergence and strict requirement of the additional intiation factor Bdp1, which is unique to the RNA polymerase (RNAP) III sytem, however, remained elusive. A poorly studied aspect in this context ...

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J. Am. Chem. Soc. 2019, 141, 13643−13653, DOI: 10.1021/jacs.9b06521
J. Am. Chem. Soc., online article

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Psoralens are natural compounds that serve in the light dependent treatment of certain skin diseases (PUVA therapy). They are DNA intercalators that upon photoexcitation form adducts with thymine bases. For one psoralen derivative, 4′-aminomethyl-4,5′,8-trimethylpsoralen (AMT), the photoreactions are characterized here by nanosecond UV–vis and IR absorption ...

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Scientific Reports, volume 9, Article number: 6003 (2019), https://doi.org/10.1038/s41598-019-42026-y
Scientific Reports, online article

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Bisacylphosphane oxides (BAPOs) are established as photoinitiators for industrial applications. Light irradiation leads to their photolysis, producing radicals. Radical species induce oxidative stress in cells and may cause cell death. Hence, BAPOs may be suitable as photolatent cytotoxic agents, but such applications have not been investigated yet. Herein, we ...

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Nanoscale, 2019, 11, 7674, DOI: 10.1039/c9nr01204d
Nanoscale, online article

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Metallic nanoparticles were shown to affect Förster energy transfer between fluorophore pairs. However, to date, the net plasmonic effect on FRET is still under dispute, with experiments showing efficiency enhancement and reduction. This controversy is due to the challenges involved in the precise positioning of FRET pairs in the near field of a metallic ...

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Nano Lett., 2019, 19 (2), pp 1275–1281, DOI: 10.1021/acs.nanolett.8b04845
Nano Lett., online article

 

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An ideal point light source is as small and as bright as possible. For fluorescent point light sources, homogeneity of the light sources is important as well as that the fluorescent units inside the light source maintain their photophysical properties, which is compromised by dye aggregation. Here we propose DNA origami as a rigid scaffold to arrange dye ...

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PNAS, www.pnas.org/cgi/doi/10.1073/pnas.1816698116
PNAS, online article

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A common design principle of heteromeric signaling proteins is the use of shared subunits. This allows encoding of complex messages while maintaining evolutionary flexibility. How cells regulate and control assembly of such composite signaling proteins remains an important open question. An example of particular complexity and biological relevance is the ...

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