Research Area C - Publications 2019
Cell, 179, 1264–1275, DOI:https://doi.org/10.1016/j.cell.2019.11.001
Cell, online article
TLR8 is among the highest-expressed pattern-recognition receptors in the human myeloid compartment, yet its mode of action is poorly understood. TLR8 engages two distinct ligand binding sites to sense RNA degradation products, although it remains unclear how these ligands are formed in cellulo in the context of complex RNA molecule sensing. Here, we identified ...
Challenges and perspectives for structural biology of lncRNAs—the example of the Xist lncRNA A-repeats
Journal of Molecular Cell Biology, Volume 11, Issue 10, Pages 845–859, https://doi.org/10.1093/jmcb/mjz086
Journal of Molecular Cell Biology, online article
Following the discovery of numerous long non-coding RNA (lncRNA) transcripts in the human genome, their important roles in biology and human disease are emerging. Recent progress in experimental methods has enabled the identification of structural features of lncRNAs. However, determining high-resolution structures is challenging as lncRNAs are expected to be ...
Nature Structural & Molecular Biology, volume 26, pages 361–371 (2019), https://doi.org/10.1038/s41594-019-0219-9
Nature Structural & Molecular Biology, online article
Histone lysine methylation is generally performed by SET domain methyltransferases and regulates chromatin structure and gene expression. Here, we identify human C21orf127 (HEMK2, N6AMT1, PrmC), a member of the seven-β-strand family of putative methyltransferases, as a novel histone lysine methyltransferase. C21orf127 functions as an obligate heterodimer with ...