Funktionalisierung αvβ3- oder α5β1-selektiver Integrinantagonisten für die Oberflächenbeschichtung: ein Hilfsmittel zur Unterscheidung von Integrinsubtypen in vitro
Angewandte Chemie, 2012, DOI: 10.1002/ange.201206370, Volume 125, Issue 5, pages 1612–1616 published on 12.12.2012
Investigating the different functions of distinct surface receptors is essential to understand the complex interactions between cells and their extracellular environment. Cells use specific transmembrane receptors of the integrin family to anchor and respond to extracellular matrix (ECM) proteins. In doing so, integrins are capable of regulating cell migration, survival, cell cycle progression, and differentiation, which are essential tasks for the development of all multicellular organisms. Integrins are often classified according to their binding specificity for extracellular ligands.