Towards molecular systems biology of gene transcription and regulation
Biological Chemistry, 2010, DOI 10.1515/BC.2010.094, Vol. 391, pp. 731–735 published on 19.05.2010
Ten years after the determination of the RNA polymerase II structure, the basic mechanism of mRNA synthesis during gene transcription is known. In the future, the initiation and regulation of transcription must be studied with a combination of structural biology, biochemistry, functional genomics, and computational methods. In this article, the efforts of our laboratory to move from an integrated structural biology of gene transcription towards molecular systems biology of gene regulation are reviewed.