Expanding the Structural Space of Ribosomal Peptides: Autocatalytic N‐Methylation in Omphalotin Biosynthesis

Angew. Chem. Int. Ed., Volume56, Issue44, Pages 13570-13572, https://doi.org/10.1002/anie.201708456
Angew. Chem. Int. Ed., online article

The N‐methylation of backbone amide bonds in peptide natural products was thought to be exclusive to non‐ribosomal peptides. A newly discovered methylation mechanism now brings this structural feature into the world of ribosomal peptides, thereby significantly expanding the structural diversity of ribosomally synthesized and post‐translationally modified peptides (RiPPs).

TU München
Helmholtz München
MPI of Neurobiology
MPI of Biochemistry