Research Area E - Publications 2019
Excursion of the CIPSM Integrated Graduate Forum to the Bayer AG as part of the lecture on Innovations Management of Alumnus Bayer AG Board of Management Member Wolfgang Plischke.
Date of the excursion: Tuesday 12. may 2020
Excursion of students from the CIPSM graduate educational program to the Bayer AG as part of the lecture series on Innovations Management of Bayer AGs former Board of Management Member Wolfgang Plischke.
Please register here: postponed indefinitely due to the current situation
It’s Christmas and we at CIPSM just wanted to say
Thank you and that it’s been a pleasure working with you this past year.
We wish you and your family wonderful holidays and a Happy New Year!
Nat Commun 10, 5600 (2019) doi:10.1038/s41467-019-13565-9
Nat Commun., online article
RNAs contain post-transcriptional modifications, which fulfill a variety of functions in translation, secondary structure stabilization and cellular stress survival. Here, 2-methylthiocytidine (ms2C) is identified in tRNA of E. coli and P. aeruginosa using NAIL-MS (nucleic acid isotope labeling coupled mass spectrometry) in combination with genetic screening ...
Cell, 179, 1264–1275, DOI:https://doi.org/10.1016/j.cell.2019.11.001
Cell, online article
TLR8 is among the highest-expressed pattern-recognition receptors in the human myeloid compartment, yet its mode of action is poorly understood. TLR8 engages two distinct ligand binding sites to sense RNA degradation products, although it remains unclear how these ligands are formed in cellulo in the context of complex RNA molecule sensing. Here, we identified ...
Science, Vol. 366, Issue 6461, pp. 76-82, DOI: 10.1126/science.aax2747
Science, online article
Theories about the origin of life require chemical pathways that allow formation of life’s key building blocks under prebiotically plausible conditions. Complex molecules like RNA must have originated from small molecules whose reactivity was guided by physico-chemical processes. RNA is constructed from purine and pyrimidine nucleosides, both of which are ...
Mitochondrial Alkbh1 localizes to mtRNA granules and its knockdown induces the mitochondrial UPR in humans and C. elegans
Journal of Cell Science; 2019; 132: jcs223891; doi: 10.1242/jcs.223891
Journal of Cell Science, online article
The Fe(II) and 2-oxoglutarate-dependent oxygenase Alkb homologue 1 (Alkbh1) has been shown to act on a wide range of substrates, like DNA, tRNA and histones. Thereby different enzymatic activities have been identified including, among others, demethylation of N3-methylcytosine (m3C) in RNA- and single-stranded DNA oligonucleotides, demethylation of ...
19th to the 20th of September 2019
The Scientific Oktoberfest will be this years meeting point for some of the internationally most distinguished researchers in the field of Life Science Chemistry & Biology.
The CIPSM Scientific Oktoberfest will be held from the 19th to the 20th of September at the Institute of Advanced Study IAS in Garching near Munich. At the two-day conference, researchers ...
Wir freuen uns über ein gelungenes Richtfest des neuen Institutes für Chemische Epigenetik am 13.5.2019 auf dem Campus Großhadern.
Wir danken mit Nachdruck allen Arbeitern, Ingenieuren, Architekten und Planern, die unseren schönen Forschungsbau so schnell und professionell erbaut haben.
Großer Dank gilt Sigrid Bauer für ihre ausgezeichnete Organisation des ...
Prof. Thomas Carell from CIPSM and Dr. Alexander Karp, founder and CEO of Palantir Technologies (Palo Alto) were elected into the BASF supervisory board (Aufsichtsrat).
Characterization of a novel cytochrome cGJ as the electron acceptor of XoxF-MDH in the thermoacidophilic methanotroph Methylacidiphilum fumariolicum SolV
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, Volume 1867, Issue 6, Pages 595-603, https://doi.org/10.1016/j.bbapap.2019.04.001
BBA, online article
Methanotrophs play a prominent role in the global carbon cycle, by oxidizing the potent greenhouse gas methane to CO2. Methane is first converted into methanol by methane monooxygenase. This methanol is subsequently oxidized by either a calcium-dependent MxaF-type or a lanthanide-dependent XoxF-type methanol dehydrogenase (MDH). Electrons from methanol oxidation ...
Nature Communications, volume 10, Article number: 672, https://doi.org/10.1038/s41467-019-08632-0
Nature Communications, online article
A fundamental step in membrane protein biogenesis is their integration into the lipid bilayer with a defined orientation of each transmembrane segment. Despite this, it remains unclear how cells detect and handle failures in this process. Here we show that single point mutations in the membrane protein connexin 32 (Cx32), which cause Charcot-Marie-Tooth disease, ...