Exploring the Pharmacology and Action Spectra of Photochromic Open-Channel Blockers

ChemBioChem, 2012, DOI: 10.1002/cbic.201200216, Volume 13, Issue 12, pages 1746–1749 published on 13.07.2012

ChemBioChem, online article

Light control of voltage-gated ion channels: We have developed red-shifted derivatives of QAQ, a powerful doubly charged photochromic blocker. These derivatives allow for remote control of Kv and Nav channel conductance with light and offer the opportunity to silence neuronal activity reversibly.

TU München
Helmholtz München
MPI of Neurobiology
MPI of Biochemistry