Rescuing DNA repair activity by rewiring the H-atom transfer pathway in the radical SAM enzyme, spore photoproduct lyase

Chemical Communications, 2014, DOI: 10.1039/C4CC05158K, 50, 14201-14204 published on 19.09.2014
Chemical Communications, online article
The radical SAM enzyme, spore photoproduct lyase, requires an H-atom transfer (HAT) pathway to catalyze DNA repair. By rational engineering, we demonstrate that it is possible to rewire its HAT pathway, a first step toward the development of novel catalysts based on the radical SAM enzyme scaffold.  

TU München
Helmholtz München
MPI of Neurobiology
MPI of Biochemistry