β-Sultams exhibit discrete binding preferences for diverse bacterial enzymes with nucleophilic residues
30-Oct-2013
Chem. Commun., 2013, DOI: 10.1039/C3CC46002A, 50, 427-429 published on 30.10.2013
Chem. Commun., online article
Chem. Commun., online article
β-Sultams are potent electrophiles that modify nucleophilic residues in selected enzyme active sites. We here identify and characterize some of the specific bacterial targets and show a unique inhibition of the azoreductase family.
