Controlling the Structure of Proteins at Surfaces

JACS, 2010, doi:10.1021/ja107212z, published on 16.11.2010
JACS, online article
With the help of single molecule force spectroscopy and molecular dynamics simulations, we determine the surface-induced structure of a single engineered spider silk protein. An amyloid like structure is induced in the vicinity of a surface with high surface energy and can be prohibited in the presence of a hydrophobic surface. The derived molecular energy landscapes highlight the role of single silk protein structure for the macroscopic toughness of spider silk.

TU München
Helmholtz München
MPI of Neurobiology
MPI of Biochemistry