Comment on “Drosophila Dosage Compensation Involves Enhanced Pol II Recruitment to Male X-Linked Promoters”

Science, 2013, DOI: 10.1126/science.1231895, Vol. 340 no. 6130 p. 273 published on 19.04.2013
Science, online article
Conrad et al. (Reports, 10 August 2012, p. 742) reported that Drosophila dosage compensation might largely be due to increased recruitment of RNA polymerase II to promoters. A reassessment of the numerical operations revealed that the authors’ calculations are severely confounded by an inappropriate numerical procedure. A rectified analysis strongly suggests that the authors’ conclusions are not supported by their data.

TU München
Helmholtz München
MPI of Neurobiology
MPI of Biochemistry