Getting Access to Low-Complexity Domain Modifications
Trends in Biochemical Sciences, DOI: http://dx.doi.org/10.1016/j.tibs.2016.05.010
Trends in Biochemical Sciences, online article
Low-complexity (LC) domains regulate the aggregation and phase transition of proteins in a modification-dependent manner. The study of LC domain modifications has now become feasible, as shown by genetic variants of the carboxy-terminal domain (CTD) of RNA Polymerase II (Pol II) that provide access to the type and position of modifications of a LC domain by mass spectrometry (MS).