Histidine kinases and response regulators in networks

Current Opinion in Microbiology, 2011, DOI 10.1016/j.mib.2011.11.009, 15, 1–7 published on 13.12.2011
Current Opinion in Microbiology, online article
Two-component systems, composed of a histidine kinase (HK) and a response regulator (RR), are the major signal transduction devices in bacteria. Originally it was thought that these two components function as linear, phosphorylationdriven stimulus–response system. Here, we will review how accessory proteins are employed by HKs and RRs to mediate signal integration, scaffolding, interconnection and allosteric regulation, and how these two components are embedded in regulatory networks.

TU München
Helmholtz München
MPI of Neurobiology
MPI of Biochemistry