Histone H3 Glutathionylation in Proliferating Mammalian Cells Destabilizes Nucleosomal Structure
21-May-2013
Mary Ann Liebert, Inc. publishers, 2013, DOI: 10.1089/ars.2012.5021, published on 21.05.2013
Mary Ann Liebert, Inc. publishers, online article
Mary Ann Liebert, Inc. publishers, online article
Here we report that chromatin, the complex and dynamic eukaryotic DNA packaging structure, is able to sense cellular redox changes. Histone H3, the only nucleosomal protein that possesses cysteine(s), can be modified by glutathione (GSH).